杨其帆, 沈冰, 蔡菁婷, 刘仲苓, 李颐, 凤思超, 周一卉, 陆巳岚, 赵红, 叶芷玲, 熊建菁. 上海市室内灰尘中邻苯二甲酸酯分布及人群暴露风险评估[J]. 上海预防医学, 2022, 34(3): 247-251. DOI: 10.19428/j.cnki.sjpm.2022.20976
引用本文: 杨其帆, 沈冰, 蔡菁婷, 刘仲苓, 李颐, 凤思超, 周一卉, 陆巳岚, 赵红, 叶芷玲, 熊建菁. 上海市室内灰尘中邻苯二甲酸酯分布及人群暴露风险评估[J]. 上海预防医学, 2022, 34(3): 247-251. DOI: 10.19428/j.cnki.sjpm.2022.20976
YANG Qifan, SHEN Bing, CAI Jingting, LIU Zhongling, LI Yi, FENG Sichao, ZHOU Yihui, LU Silan, ZHAO Hong, YE Zhiling, XIONG Jianjing. Distribution and exposure assessment of phthalic acid estersPAEsin indoor dust of Shanghai[J]. Shanghai Journal of Preventive Medicine, 2022, 34(3): 247-251. DOI: 10.19428/j.cnki.sjpm.2022.20976
Citation: YANG Qifan, SHEN Bing, CAI Jingting, LIU Zhongling, LI Yi, FENG Sichao, ZHOU Yihui, LU Silan, ZHAO Hong, YE Zhiling, XIONG Jianjing. Distribution and exposure assessment of phthalic acid estersPAEsin indoor dust of Shanghai[J]. Shanghai Journal of Preventive Medicine, 2022, 34(3): 247-251. DOI: 10.19428/j.cnki.sjpm.2022.20976

上海市室内灰尘中邻苯二甲酸酯分布及人群暴露风险评估

Distribution and exposure assessment of phthalic acid estersPAEsin indoor dust of Shanghai

  • 摘要:
    目的 探讨上海市不同场所室内灰尘中邻苯二甲酸酯(PAEs)的分布特征并评估人群暴露的健康风险。
    方法 2018年、2019年、2020年对上海市部分居民家庭、办公室、公共场所室内灰尘进行采样分析,共采集到灰尘样品33份。样品经过100筛,提取浓缩后,经气相色谱-质谱联用仪选择离子模式(SIM)检测分析,研究其构成情况、分布特征及人群暴露情况。
    结果 对不同场所室内灰尘中PAEs的分布特征研究表明,PAEs的16种单体均有检出,浓度范围为<0.01~2 464 mg·kg-1,平均含量为613 mg·kg-1,主要以邻苯二甲酸二(2-乙基己基)酯(DEHP)、邻苯二甲酸二异丁酯(DiBP)、邻苯二甲酸二丁酯(DBP)和邻苯二甲酸二正辛酯(DNOP)为主,约占16种PAEs的99.5%。不同功能区的PAEs浓度由高到低为家庭>办公室>宾馆>车站。DEHP、DBP、邻苯二甲酸二乙酯(DEP)及邻苯二甲酸丁基苄酯(BBP)的日均暴露量均低于欧洲生态毒理学及环境科学研究会、美国环境保护署(EPA)规定的日耐受量(TDI)与参考剂量(RfD)。室内灰尘中DEHP对儿童和成人的致癌风险(R)分别为6.63×10-5和1.02×10-5
    结论 人群中不同途径暴露室内灰尘的PAEs的日均摄入量顺序为手-口摄入>皮肤接触>呼吸吸入。儿童暴露风险大于成人。

     

    Abstract:
    Objective To characterize the distribution and assess the exposure to phthalic acid esters (PAEs) in the indoor dust of Shanghai City.
    Methods Samples were collected from 33 sampling sites, including homes, hotels, offices and public places, in Shanghai in 2018, 2019, and 2020. The samples were pretreated by 100 sieves, extracted and concentrated, and then analyzed by gas chromatography-mass spectrometry in selected ion mode (SIM).
    Results Results on the characteristics of PAEs in indoor dust in different places showed that concentrations of PAEs were in a range of <0.01-2 464 mg·kg-1.The average concentration of 16 PAEs was 613 mg·kg-1. Bis(2-ethylhexyl) phthalate (DEHP), di-iso-butyl phthalate (DiBP), di-n-butyl phthalate (DBP) and di-n-octyl phthalate (DnOP) were the main components of PAEs in indoor dust, accounting for approximately 99.5% of 16 PAEs. The intake of DEHP, DBP, DEP and BBP was lower than the tolerable daily intake (TDI) and reference doses (RfD) set by EU CSTEE and U.S. EPA.
    Conclusion Average daily dose (ADD) via indoor dust is estimated, and the order of intake through different pathways is hand-oral intake>skin contact>respiratory inhalation. Exposure risk of PAEs in children is greater than that in adults.

     

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