莫艳萍, 施旭斌, 费静娴. 浙江省湖州地区献血人群隐匿性乙型肝炎病毒感染状况[J]. 上海预防医学, 2022, 34(3): 197-200. DOI: 10.19428/j.cnki.sjpm.2022.21024
引用本文: 莫艳萍, 施旭斌, 费静娴. 浙江省湖州地区献血人群隐匿性乙型肝炎病毒感染状况[J]. 上海预防医学, 2022, 34(3): 197-200. DOI: 10.19428/j.cnki.sjpm.2022.21024
MO Yanping, SHI Xubin, FEI Jingxian. Prevalence of occult HBV infection among blood donors in Huzhou City,Zhejiang Province[J]. Shanghai Journal of Preventive Medicine, 2022, 34(3): 197-200. DOI: 10.19428/j.cnki.sjpm.2022.21024
Citation: MO Yanping, SHI Xubin, FEI Jingxian. Prevalence of occult HBV infection among blood donors in Huzhou City,Zhejiang Province[J]. Shanghai Journal of Preventive Medicine, 2022, 34(3): 197-200. DOI: 10.19428/j.cnki.sjpm.2022.21024

浙江省湖州地区献血人群隐匿性乙型肝炎病毒感染状况

Prevalence of occult HBV infection among blood donors in Huzhou City,Zhejiang Province

  • 摘要:
    目的 探索湖州地区献血人群隐匿性乙型肝炎病毒(HBV)感染(occult hepatitis B virus infection,OBI)的流行状况及特征。
    方法 选取2018年10月—2020年2月期间收集的31 348份献血者标本,采用血清学和核酸检测技术对HBV感染标志物进行检测。根据检测结果,将27例乙型肝炎表面抗原(HBsAg)双阴性(2种试剂检测)、核酸扩增技术(NAT)阳性的标本确定为OBI组;25例HBsAg双阳性(2种试剂检测)、NAT阳性标本作为显性HBV感染组。分别进行HBV核酸定量检测、血清乙肝三系标志物、肝功能标志物检测,并对2组结果进行比较分析。
    结果 献血者标本中HBsAg阴性为31 034例,其中27例HBV⁃DNA阳性,OBI流行率为0.87‰。27例OBI者中共发现6种血清学,其中乙型肝炎核心抗体(HBcAb)检出25例(92.6%),乙型肝炎表面抗体(HBsAb)检出17例(63.0%),乙型肝炎E抗体(HBeAb)检出17例(63.0%),HBcAb、HBsAb联合检出15例(55.6%),HBcAb、HBeAb联合检出14例(51.9%)。OBI组和显性感染组相比,性别、HBcAb阳性率、总胆红素(TBI)、天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)肝炎生化指标差异无统计学意义(P>0.05),年龄和HBsAb水平差异有统计学意义(χ2=1.201,P<0.001;t=28.336,P<0.001),平均HBV⁃DNA载量为(25.86±19.68) IU·mL-1,明显低于对照组[(3 254.65±535.98) IU·mL-1](t=32.412,P<0.01)。
    结论 湖州地区献血者中存在一定OBI者,其血清学以HBcAb、HBsAb为主,血清学检测联合核酸检测,可保障输血安全,降低经血传播乙型肝炎的风险。

     

    Abstract:
    Objective To explore the prevalence and characteristics of occult hepatitis B virus infection (OBI) among blood donors in Huzhou region.
    Methods A total of 31 348 blood donors collected from October 2018 to February 2020 were selected for detecting HBV infection markers by serological and nucleic acid detection techniques. According to the detection results, 27 cases of HBsAg double negative (two kinds of reagent detection), nucleic acid amplification technology (NAT) positive samples were identified as the occult HBV infection group (OBI group); 25 cases of HBsAg double positive (two kinds of reagent detection), NAT positive samples were identified as dominant HBV infection group, respectively. HBV nucleic acid quantitative detection, serum hepatitis B three line markers, liver function markers detection, and the results of the two groups were compared and analyzed.
    Results There were 31 034 HBsAg negative blood donors, 27 of whom were HBV-DNA positive, and the prevalence of OBI was 0.87 ‰. Six kinds of serology were found in 27 OBI patients, among which 25 cases (92.6%) were HBcAb, 17 cases (63.0%) were HBsAb, 17 cases (63.0%) were HBeAb, 15 cases (55.6%) were HBcAb and HBsAb, and 14 cases (51.9%) were HBcAb and HBeAb. There was no significant difference in gender, HBcAb positive rate, TBI, AST and ALT between the two groups (P>0.05). There were significant differences in age and HBsAb level (χ2=1.201, P<0.001; t=28.336, P<0.001), and the average viral load was (25.86±19.68) IU/mL, which was significantly lower than the average viral load of the control group (3 254.65±535.98)IU/mL(t=32.412, P<0.01).
    Conclusion There is a certain prevalence of OBI in blood donors in Huzhou area. The main kinds of serology are HBcAb and HBsAb. Serological detection combined with nucleic acid detection can ensure the safety of blood transfusion and reduce the risk of blood borne diseases.

     

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