陆玲玲, 程妤奋, 游兴姬, 丁晓颖, 邢秋霞, 熊晨菡, 顾丽芳, 朱芸, 王晓波, 黄鹰, 杨伶俐. 妊娠中期孕妇血清IL-1、IL-6、IL-8、TNF-a及CRH浓度预测早产的初探[J]. 上海预防医学, 2018, 30(12): 1029-1033. DOI: 10.19428/j.cnki.sjpm.2018.19065
引用本文: 陆玲玲, 程妤奋, 游兴姬, 丁晓颖, 邢秋霞, 熊晨菡, 顾丽芳, 朱芸, 王晓波, 黄鹰, 杨伶俐. 妊娠中期孕妇血清IL-1、IL-6、IL-8、TNF-a及CRH浓度预测早产的初探[J]. 上海预防医学, 2018, 30(12): 1029-1033. DOI: 10.19428/j.cnki.sjpm.2018.19065
shu
LU Ling-ling, CHENG Yu-fen, YOU Xing-ji, DING Xiao-ying, XING Qiu-xia, XIONG Chen-han, GU Li-fang, ZHU Yun, WANG Xiao-bo, HUANG Ying, YANG Ling-li. Second-trimester serum IL-1, IL-6, IL-8, TNF-a, CRH levels in prediction of preterm labor[J]. Shanghai Journal of Preventive Medicine, 2018, 30(12): 1029-1033. DOI: 10.19428/j.cnki.sjpm.2018.19065
Citation: LU Ling-ling, CHENG Yu-fen, YOU Xing-ji, DING Xiao-ying, XING Qiu-xia, XIONG Chen-han, GU Li-fang, ZHU Yun, WANG Xiao-bo, HUANG Ying, YANG Ling-li. Second-trimester serum IL-1, IL-6, IL-8, TNF-a, CRH levels in prediction of preterm labor[J]. Shanghai Journal of Preventive Medicine, 2018, 30(12): 1029-1033. DOI: 10.19428/j.cnki.sjpm.2018.19065
shu

妊娠中期孕妇血清IL-1、IL-6、IL-8、TNF-a及CRH浓度预测早产的初探

Second-trimester serum IL-1, IL-6, IL-8, TNF-a, CRH levels in prediction of preterm labor

    摘要
  • 摘要:
    目的探讨妊娠中期(孕24~28周)无症状孕妇血清IL-1、IL-6、IL-8、TNF-a及CRH浓度与早产的关系。
    方法选择2015年1月—2017年12月在上海市浦东新区妇幼保健院定期产检，孕24~28周无症状的孕妇，抽取其静脉血，采样冻存待测。随访其妊娠结局，根据妊娠结局选择早产组100例，包括自发性早产71例和未足月胎膜早破29例，并选择同期足月分娩者100例为对照组。采用ELISA法检测血清IL-1、IL-6、IL-8、TNF-a和CRH的浓度。两组产后胎膜送病理检查，判断有无绒毛膜羊膜炎。
    结果早产组孕24~28周血清IL-1、IL-6、IL-8浓度高于对照组(P < 0.05), 血清TNF-a、CRH浓度无明显升高(P>0.05)。早产绒毛膜羊膜炎组血清IL-6、IL-8浓度高于早产非绒毛膜羊膜炎组和对照组，早产非绒毛膜羊膜炎组和对照组差异无统计学意义(P < 0.05)；早产绒毛膜羊膜炎组的血清IL-1浓度与早产非绒毛膜羊膜炎组比较，差异无统计学意义，但明显高于对照组(P < 0.05)。3组间血清TNF-a和CRH的浓度差异无统计学意义(P>0.05)。血清IL-1预测早产的ROC曲线下面积(AUC)为0.843，最佳界值为10.699 pg/mL；IL-6的AUC为0.675，最佳界值为104.411 pg/mL；IL-8的AUC为0.55，最佳界值为65.496 pg/mL。
    结论孕24~28周无症状孕妇的血清IL-1、IL-6、IL-8水平对预测早产有一定的价值。

     

    Abstract:
    ObjectiveTo determine the relationship between maternal serum IL-1, IL-6, IL-8, TNF-a and CRH levels and preterm labor in asymptomatic women at 24 to 28 weeks′ gestation.
    MethodsWe performed a prospective cohort study from January 2015 to December 2017 for asymptomatic women at 24 to 28 weeks′ gestation and maternal serum.According to the pregnancy outcome, 100 cases of preterm labor were selected as experimental group and another 100 cases of term labor as control group.The levels of serum IL-1, IL-6, IL-8, TNF-a and CRH were measured by ELISA.The partial membranes of all cases were examined pathologically after labor.
    ResultsThe levels of serum IL-1, IL-6 and IL-8 in preterm labor group were significantly higher than those in the control group(P < 0.05).The levels of serum IL-6 and IL-8 in preterm labor with chorioamnionitis were significantly higher than those without chorioamnionitis and term labor(P < 0.05).The level of IL-1 in preterm labor without chorioamnionitis was significantly higher than that of term labor(P < 0.05).The levels of serum TNF-a and CRH had no difference between the groups(P>0.05).Receiver-operating characteristic curves demonstrated that serum IL-1, IL-6 and IL-8 predicted preterm labor.The area under the curve (AUC) of IL-1 was 0.843.The AUC of IL-6 was 0.675 and IL-8 was 0.55.
    ConclusionMaternal serum IL-1, IL-6 and IL-8 in asymptomatic women at 24 to 28 weeks′ gestation are useful markers for prediction of preterm labor.

     

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