Abstract: Shanghai public health service-community colorectal cancer screening program, was officially launched in November 2012, so as to carry out colorectal cancer prevention and health education through free screening services in the whole city. The establishment of the program was based on the comprehensive analysis of disease burden caused by colorectal cancer in Shanghai, with three years of pilot study in Qibao Community. In the first round of screening, one million people participated and 1 960 colorectal cancer cases were detected, with the proportion of the earlier stage cancer being 52.8%, which was 4.36 times the level in Shanghai before screening. At the same time, 7 911 cases of precancerous lesion were detected. The objective of program was achieved, with precious experience obtained in implementation of similar disease screening programs.