陆莉, 杨柳. 芎红活血外洗方预防卡培他滨相关手足综合征效果观察[J]. 上海预防医学, 2019, 31(6): 510-513. DOI: 10.19428/j.cnki.sjpm.2019.19243
引用本文: 陆莉, 杨柳. 芎红活血外洗方预防卡培他滨相关手足综合征效果观察[J]. 上海预防医学, 2019, 31(6): 510-513. DOI: 10.19428/j.cnki.sjpm.2019.19243
LU Li, YANG Liu. Herbal fumigation applied in prevention and treatment of hand-foot syndrome induced by capecitabine:Obervation on its curative effect[J]. Shanghai Journal of Preventive Medicine, 2019, 31(6): 510-513. DOI: 10.19428/j.cnki.sjpm.2019.19243
Citation: LU Li, YANG Liu. Herbal fumigation applied in prevention and treatment of hand-foot syndrome induced by capecitabine:Obervation on its curative effect[J]. Shanghai Journal of Preventive Medicine, 2019, 31(6): 510-513. DOI: 10.19428/j.cnki.sjpm.2019.19243

芎红活血外洗方预防卡培他滨相关手足综合征效果观察

Herbal fumigation applied in prevention and treatment of hand-foot syndrome induced by capecitabine:Obervation on its curative effect

  • 摘要:
    目的探讨芎红活血外洗方手足浸泡方法对卡培他滨化疗后手足综合征(hand-foot syndrome,HFS)的预防作用。
    方法随机将67例接受含卡培他滨化疗的胃肠道恶性肿瘤患者分为2组,实验组(34人)采用基础护理及芎红活血外洗方手足浸泡治疗,对照组(33人)予以基础护理及温水浸泡。使用卡培他滨化疗的同时开始对两组人群予以相应治疗。
    结果实验组HFS发生率显著低于对照组(17.6%与42.4%,P=0.027),且发生时间显著晚于对照组(P=0.032)。对照组患者的手足疼痛症状较实验组患者明显(P=0.002)。是否使用中药浸泡(OR=3.280,P=0.040)是HFS发生的独立危险因素。对照组中,卡培他滨联合紫杉醇患者的HFS发生率,高于卡培他滨联合奥沙利铂的患者(P=0.047)。
    结论芎红活血外洗方手足浸泡对卡培他滨相关性HFS具有很好的预防作用。

     

    Abstract:
    ObjectiveTo investigate the curative effect of early application of the herbal fumigation on hand-foot syndrome (HFS) induced by capecitabine.
    MethodsA series of 67 patients with gastrointestinal malignancies receiving capecitabine chemotherapy were randomly divided into two groups.The treatment group (34 patients) was treated with herbal immersion and basic care, while the control group (33 patients) with warm water immersion and basic care.The corresponding treatment was adopted as soon as the chemotherapy with capecitabine was started.
    ResultsThe incidence and occurrence time of HFS in the treatment group were significantly lower (17.6% vs 42.4%, P=0.027) and later (P=0.032) than that in the control group.The symptoms of pain in the control group were more significant than those in the treatment group (P=0.002).Treatment without herbal immersion (OR=3.280, P=0.040) were independently related to HFS.In the control group, the incidence of HFS in patient taking capecitabine and paclitaxel were significantly higher than those taking capecitabine and oxaliplatine (P=0.047).
    ConclusionHerbal immersion has preventive and therapeutic effect on hand-foot syndrome caused by capecitabine.

     

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