杨守飞, 黄卓英, 任佳, 刘捷宸. 2010—2020年上海市肺炎疫苗的疑似预防接种异常反应报告的分析[J]. 上海预防医学, 2021, 33(6): 548-552. DOI: 10.19428/j.cnki.sjpm.2021.21138
引用本文: 杨守飞, 黄卓英, 任佳, 刘捷宸. 2010—2020年上海市肺炎疫苗的疑似预防接种异常反应报告的分析[J]. 上海预防医学, 2021, 33(6): 548-552. DOI: 10.19428/j.cnki.sjpm.2021.21138
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YANG Shou-fei, HUANG Zhuo-ying, REN Jia, LIU Jie-chen. Analysis on the suspected adverse events following immunization surveillance reports of pneumonia vaccine in Shanghai， 2010‒2020[J]. Shanghai Journal of Preventive Medicine, 2021, 33(6): 548-552. DOI: 10.19428/j.cnki.sjpm.2021.21138
Citation: YANG Shou-fei, HUANG Zhuo-ying, REN Jia, LIU Jie-chen. Analysis on the suspected adverse events following immunization surveillance reports of pneumonia vaccine in Shanghai， 2010‒2020[J]. Shanghai Journal of Preventive Medicine, 2021, 33(6): 548-552. DOI: 10.19428/j.cnki.sjpm.2021.21138
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2010—2020年上海市肺炎疫苗的疑似预防接种异常反应报告的分析

Analysis on the suspected adverse events following immunization surveillance reports of pneumonia vaccine in Shanghai， 2010‒2020

    摘要
  • 摘要:
    目的分析上海市2010—2020年肺炎疫苗的疑似预防接种异常反应（AEFI）报告的数据，为完善上海市肺炎疫苗免疫策略和科普宣传提供参考。
    方法收集2010年1月1日—2020年12月31日中国免疫规划信息管理系统中上海市接种肺炎疫苗后发生疑似预防接种异常反应的报告数据，同时从上海市预防接种信息系统中获取上述时间段的肺炎疫苗接种信息。采用描述流行病学方法进行AEFI的描述性分析。
    结果2010—2020年上海市共报告18 446例接种肺炎疫苗后的AEFI个案，报告发生率为425.0/10万剂。其中一般反应18 003例（97.6%），异常反应393例（2.0%），偶合症57例（0.3%），心因性反应2例（<0.1%），无疫苗质量事故和接种事故的报告。AEFI的报告发生率随着受种者年龄的增加而逐渐降低；23价肺炎球菌多糖疫苗（PPV23）AEFI的报告发生率为476.5/10万剂，显著低于其他种类肺炎疫苗；首剂次接种后AEFI的报告发生率为344.5/10万剂，显著高于非首剂次接种。
    结论上海市正在使用的各类肺炎疫苗具有良好的安全性。

     

    Abstract:
    ObjectiveTo analyze the collected data of adverse events （AEFI） of pneumonia vaccine in Shanghai from 2010 to 2020，， so as to provide the appropriate immunization strategy and popularization of science for pneumonia vaccine .
    Methodsthe data of suspected adverse events were collected from National AEFI Surveillance System during 2010 to 2020， and the vaccination information of pneumonia vaccine was obtained from Shanghai Vaccination Information System. Descriptive epidemiological method was used to analysis.
    ResultsThe total 18 446 AEFI cases were reported in Shanghai from 2010 to 2020， and the incidence rate was 425.0/100 000 doses. The general reactions were reported as 18 003 cases （97.6%）， with 393 cases of abnormal reactions （2.0%）， 57 cases of coincidences （0.3%）， 2 cases of psychogenic reactions （<0.1%） and no vaccine quality accident or vaccination accident was reported. There was no significant difference in the incidence rate between male and female； The incidence rate of AEFI decreased with the age of the old. The incidence rate of 23 valent pneumococcal polysaccharide vaccine （PPV23） AEFI was 476.5/100 000 doses， which was significantly lower than that of other kinds of pneumonia vaccine. The first dose was also significantly higher than that of non-first dose.
    ConclusionThe various types of pneumonia vaccines being used in Shanghai have high safety.

     

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