赵仁嘉, 袁黄波, 张铁军, 陈兴栋, 索晨. 吸烟与遗传多态性交互作用对食管鳞状细胞癌发病风险的研究进展[J]. 上海预防医学, 2021, 33(12): 1215-1221. DOI: 10.19428/j.cnki.sjpm.2021.20919
引用本文: 赵仁嘉, 袁黄波, 张铁军, 陈兴栋, 索晨. 吸烟与遗传多态性交互作用对食管鳞状细胞癌发病风险的研究进展[J]. 上海预防医学, 2021, 33(12): 1215-1221. DOI: 10.19428/j.cnki.sjpm.2021.20919
ZHAO Ren-jia, YUAN Huang-bo, ZHANG Tie-jun, CHEN Xing-dong, SUO Chen. Effect of smoking and genetic polymorphisms interaction on the risk of esophageal squamous cell carcinoma[J]. Shanghai Journal of Preventive Medicine, 2021, 33(12): 1215-1221. DOI: 10.19428/j.cnki.sjpm.2021.20919
Citation: ZHAO Ren-jia, YUAN Huang-bo, ZHANG Tie-jun, CHEN Xing-dong, SUO Chen. Effect of smoking and genetic polymorphisms interaction on the risk of esophageal squamous cell carcinoma[J]. Shanghai Journal of Preventive Medicine, 2021, 33(12): 1215-1221. DOI: 10.19428/j.cnki.sjpm.2021.20919

吸烟与遗传多态性交互作用对食管鳞状细胞癌发病风险的研究进展

Effect of smoking and genetic polymorphisms interaction on the risk of esophageal squamous cell carcinoma

  • 摘要: 食管鳞状细胞癌(ESCC)是由环境因素和遗传因素共同作用导致的恶性肿瘤。流行病学已证实吸烟为主要环境危险因素。近年来,基因组学研究的逐渐完善,使ESCC的遗传变异影响被认识。本文综述吸烟、遗传多态性以及两者交互作用对ESCC易感性影响的研究进展,发现减少烟草的暴露时间为最有效降低发病风险的手段。在遗传层面,DNA损伤修复基因、致癌物代谢酶调控基因、细胞周期调控基因、叶酸代谢相关基因和酒精代谢相关基因的变异,可以显著提高ESCC的发病风险。吸烟与遗传多态性交互作用的研究仍然有限,需要更多的研究,以期更好地对ESCC高危人群进行筛查和预防。

     

    Abstract: Esophageal squamous cell carcinoma (ESCC) is a malignant tumor caused by both environmental and genetic factors. Epidemiology studies have identified smoking as a major environmental risk factor. In recent years, the advancement of genomics research has led to the recognition of the influence of genetic variation in ESCC. We reviewed the research progress in smoking, genetic polymorphism and their interaction on susceptibility to ESCC. Reducing exposure time to tobacco was found to be the most effective way to reduce the risk. At the genetic level, mutations in DNA repair genes, regulation genes of carcinogen-metabolizing enzymes, cell cycle regulation genes, folate metabolism related genes, and alcohol metabolism related genes were found to significantly increase the risk of ESCC. However, studies on the interaction between smoking and genetic polymorphisms in ESCC risk are still limited, more studies are needed for better screening of the high-risk populations and the prevention.

     

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