刘娜, 王临池, 胡一河, 陆艳, 黄桥梁, 陈立凌. 一级亲属癌症史对胃肠道癌症的遗传倾向影响[J]. 上海预防医学, 2018, 30(12): 1020-1024. DOI: 10.19428/j.cnki.sjpm.2018.18974
引用本文: 刘娜, 王临池, 胡一河, 陆艳, 黄桥梁, 陈立凌. 一级亲属癌症史对胃肠道癌症的遗传倾向影响[J]. 上海预防医学, 2018, 30(12): 1020-1024. DOI: 10.19428/j.cnki.sjpm.2018.18974
LIU Na, WANG Lin-chi, HU Yi-he, LU Yan, HUANG Qiao-liang, CHEN Li-ling. Gastrointestinal cancer influenced by genetic effect of cancer history of first-degree relatives[J]. Shanghai Journal of Preventive Medicine, 2018, 30(12): 1020-1024. DOI: 10.19428/j.cnki.sjpm.2018.18974
Citation: LIU Na, WANG Lin-chi, HU Yi-he, LU Yan, HUANG Qiao-liang, CHEN Li-ling. Gastrointestinal cancer influenced by genetic effect of cancer history of first-degree relatives[J]. Shanghai Journal of Preventive Medicine, 2018, 30(12): 1020-1024. DOI: 10.19428/j.cnki.sjpm.2018.18974

一级亲属癌症史对胃肠道癌症的遗传倾向影响

Gastrointestinal cancer influenced by genetic effect of cancer history of first-degree relatives

  • 摘要:
    目的比较一级亲属癌症史对胃癌、结直肠癌的遗传倾向影响大小。
    方法采用面对面调查的方法依据《人群疾病家族史和病史调查表》对苏州市某6个乡镇的胃癌、结直肠癌患者进行调查,内容包括:一般情况、一二三级亲属家系构成及一二三级亲属患癌症情况。
    结果一级亲属有癌症史,个体患胃癌的风险高于结直肠癌55%,调整OR(95%CI)为1.551(1.021,2.356);如一级亲属有消化道癌症史,这种风险会增加至104%,调整OR(95%CI)为2.037(1.279,3.246)。一级亲属有癌症史的男性患胃癌的风险高于结直肠癌91%,调整OR(95%CI)为1.911(1.080,3.381);如一级亲属有消化道癌症史的男性,这种风险会增加至156%,调整OR(95%CI)为2.559(1.337,4.897)。胃癌患者的一级亲属患癌症的人数多于结直肠癌,Z=-6.873,P < 0.001;一级亲属患消化道癌症的人数亦多于结直肠癌,Z=-6.137,P < 0.001。
    结论胃癌患者的一级亲属患癌症史、消化道癌症史均比结直肠癌患者普遍,健康教育时有必要对一级亲属有癌症史、消化道癌症史的男性进行重点宣教,提倡其改变生活习惯、定期体检,以减少胃癌的发生。

     

    Abstract:
    ObjectiveTo compare the influence of first-degree relatives′ cancer history on the genetic tendency of gastric and colorectal cancer.
    MethodsPatients with gastric and colorectal cancer from six towns of Suzhou City were investigated by means of face-to-face survey based on the "Family History and History of Population Diseases Questionnaire" which included general conditions, family composition and cancer occurrence of all their three degree relatives.
    ResultsIf there were first-degree relatives with history of cancer, individual risk of gastric cancer would be higher than that of colorectal cancer by 55%, with the adjusted OR(95%CI) being 1.551(1.021, 2.356).If there were first-degree relatives with history of digestive tract cancer, the risk of the subject would increase to 104%, with the adjusted OR(95%CI) being 2.037(1.279, 3.246).Men with first-degree relatives who had cancer history was at 91% higher risk of developing gastric cancer than colorectal cancer, with the adjusted OR(95%CI) being 1.911(1.080, 3.381).And for history of digestive tract cancer, the risk would reach 156%, with the adjusted OR(95%CI) being 2.559(1.337, 4.897).The number of cancers suffered by first-degree relatives of those patients with gastric cancer was higher than that of patients with colorectal cancer, with Z=-6.873, P < 0.001, while the number of digestive tract cancer was also higher, with Z=-6.137, P < 0.001.
    ConclusionThe history of cancer and digestive tract cancer with first-degree relatives, is more common in patients with gastric cancer than with colorectal cancer.It is necessary to focus health education on men with first-degree relatives suffering from cancer or digestive tract cancer and suggest some changes in their living habits and regular medical examinations to reduce the occurrence of gastric cancer.

     

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