史书晓, 肖萍, 田英. 孕期三氯生暴露及其对子代出生结局影响的研究进展[J]. 上海预防医学, 2021, 33(1): 84-92. DOI: 10.19428/j.cnki.sjpm.2021.20200
引用本文: 史书晓, 肖萍, 田英. 孕期三氯生暴露及其对子代出生结局影响的研究进展[J]. 上海预防医学, 2021, 33(1): 84-92. DOI: 10.19428/j.cnki.sjpm.2021.20200
SHI Shu-xiao, XIAO Ping, TIAN Ying. Triclosan exposure to pregnant women and its association with birth outcomes[J]. Shanghai Journal of Preventive Medicine, 2021, 33(1): 84-92. DOI: 10.19428/j.cnki.sjpm.2021.20200
Citation: SHI Shu-xiao, XIAO Ping, TIAN Ying. Triclosan exposure to pregnant women and its association with birth outcomes[J]. Shanghai Journal of Preventive Medicine, 2021, 33(1): 84-92. DOI: 10.19428/j.cnki.sjpm.2021.20200

孕期三氯生暴露及其对子代出生结局影响的研究进展

Triclosan exposure to pregnant women and its association with birth outcomes

  • 摘要: 三氯生(TCS)是一种广谱抗生剂,广泛应用于个人护理产品。经口/胃肠道摄入和皮肤吸收是TCS进入人体的主要途径,TCS在人体内消除的主要途径是通过尿液。研究已证实TCS能干扰甲状腺功能和生殖内分泌系统。近年来,越来越多的流行病学调查关注于妊娠期的TCS暴露及其和出生结局之间的关系。相比于其他国家,中国妊娠期妇女的TCS暴露水平较低。动物实验提示妊娠期的高剂量TCS暴露可能通过其内分泌干扰作用对出生结局产生影响。本文对孕期TCS暴露对子代出生结局影响的研究进展进行总结。

     

    Abstract: Triclosan(TCS)is a broad-spectrum antibacterial agent that is widely used in personal care products. Humans are exposed to these chemicals through oral intake or direct dermal absorption. The main way to eliminate TCS is through urine. Studies have shown that TCS may interfere with thyroid function and the reproductive endocrine system. In recent years, increasing epidemiological studies have focused on TCS exposure during pregnancy and the relationship between TCS exposure and birth outcomes. Compared with other countries and regions, pregnant women have lower levels of TCS exposure in China. Animal experiments suggested that high dose of TCS exposure during pregnancy may affect birth outcomes through its endocrine disruption. This review is aimed to summarize the effects of TCS exposure during pregnancy on the birth outcomes.

     

/

返回文章
返回