王继宝, 罗倩倩, 姚仕堂, 高洁, 杨世江, 曹艳芬, 叶润华, 杨跃诚, 何纳, 段松. 德宏州男男性行为HIV感染者抗病毒治疗现况分析[J]. 上海预防医学, 2016, 28(12): 848-852.
引用本文: 王继宝, 罗倩倩, 姚仕堂, 高洁, 杨世江, 曹艳芬, 叶润华, 杨跃诚, 何纳, 段松. 德宏州男男性行为HIV感染者抗病毒治疗现况分析[J]. 上海预防医学, 2016, 28(12): 848-852.
WANG Ji-bao, LUO Qian-qian, YAO Shi-tang, GAO Jie, YANG Shi-jiang, CAO Yan-fen, YE Run-hua, YANG Yue-cheng, HE Na, DUAN Song. Analysis of antiretroviral therapy among HIV-infected men who have sex with men in Dehong Prefecture of Yunnan Province[J]. Shanghai Journal of Preventive Medicine, 2016, 28(12): 848-852.
Citation: WANG Ji-bao, LUO Qian-qian, YAO Shi-tang, GAO Jie, YANG Shi-jiang, CAO Yan-fen, YE Run-hua, YANG Yue-cheng, HE Na, DUAN Song. Analysis of antiretroviral therapy among HIV-infected men who have sex with men in Dehong Prefecture of Yunnan Province[J]. Shanghai Journal of Preventive Medicine, 2016, 28(12): 848-852.

德宏州男男性行为HIV感染者抗病毒治疗现况分析

Analysis of antiretroviral therapy among HIV-infected men who have sex with men in Dehong Prefecture of Yunnan Province

  • 摘要: 目的 了解云南省德宏州男男性行为HIV感染者抗病毒治疗现状及影响因素。方法 收集德宏州《国家艾滋病综合防治信息系统》病例报告库和治疗库中男男性行为HIV感染者相关信息并进行统计学分析。结果 截至2016年8月,德宏州新报告男男性行为HIV感染者90例,其中中国籍71例(78.9%),外国籍19例(21.1%);68例(75.6%)已接受抗病毒治疗,中国籍病例接受抗病毒治疗的比例为83.1%,外国籍为47.4%;病例从发现到启动抗病毒治疗的时间中位数为19.5 d (IQR:7.0~66.5 d)。影响该类人群抗病毒治疗接受率的因素包括国籍(OR外籍vs中国籍=0.28,95%CI:0.09~0.93)、民族(OR少数民族vs汉族=0.31,95%CI:0.10~0.97)。51例目前在治且定期随访者的基线CD4细胞计数为(383.43±226.41)个/μL,最近一次随访CD4细胞计数为(665.63±364.10)个/μL,平均增长(282.20±276.02)个/μL;其中42例(82.4%)进行了HIV病毒载量检测,病毒完全抑制者占92.9%(39/42),病毒抑制不确定者占7.1%(3/42),无病毒抑制失败者。结论 德宏州男男性行为HIV感染者抗病毒治疗比例较高,治疗效果较好,但仍需加强外国籍、少数民族男男性行为HIV感染者的抗病毒治疗覆盖率。

     

    Abstract: Objective To examine the prevalence and influencing factors of receiving antiretroviral therapy (ART) and its effectiveness among HIV-infected men who have sex with men (MSM) in Dehong Prefecture of Yunnan Province. Methods Data were collected from the National Information System for Comprehensive AIDS Prevention and Control, tabulated descriptively and were further subject to statistical analysis. Results In total 90 participants were recruited for the study, among which 71(78.9%) were Chinese and 19 (21.1%) were foreigners,of whom 68(75.6%) have received ART. The median days from diagnosis of HIV infection to ART initiation was 19.5(IQR:7.0-66.5). Logistic regression analysis indicated that receiving ART was significantly associated with nationality (ORforeigners vs Chinese=0.28, 95%CI:0.09-0.93) and ethnicity(ORminorities vs Han=0.31,95%CI:0.10-0.97). Fifty-one participants were currently under ART and routine follow-up. Among them, the average CD4 cell account was (383.43±226.41)/μL at baseline and (665.63±364.10)/μL at the last follow-up visit,with an increase of (282.20±276.02)/μL. Forty-two (82.4%) of them were tested for plasma HIV viral load (VL). Of them, 92.85%(39/42) had undetectable VL (<50 copies/mL),3 (7.14%) had VL between 50 copies/mL to <1 000 copies/mL, with no cases having VL>1 000 copies/mL. ConclusionThe percentage of receiving ART among HIV-infected MSM in Dehong Prefecture is relatively high, with fairly good effectiveness of treatment. More efforts are needed to improve ART coverage among foreigners and ethnic minorities.

     

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