任帆. 浙江省湖州地区就诊儿童呼吸道合胞病毒感染的流行特征[J]. 上海预防医学, 2022, 34(4): 318-321. DOI: 10.19428/j.cnki.sjpm.2022.21194
引用本文: 任帆. 浙江省湖州地区就诊儿童呼吸道合胞病毒感染的流行特征[J]. 上海预防医学, 2022, 34(4): 318-321. DOI: 10.19428/j.cnki.sjpm.2022.21194
REN Fan. Epidemiological characteristics of respiratory syncytial virus infection among hospitalized children in Huzhou area,Zhejiang Province[J]. Shanghai Journal of Preventive Medicine, 2022, 34(4): 318-321. DOI: 10.19428/j.cnki.sjpm.2022.21194
Citation: REN Fan. Epidemiological characteristics of respiratory syncytial virus infection among hospitalized children in Huzhou area,Zhejiang Province[J]. Shanghai Journal of Preventive Medicine, 2022, 34(4): 318-321. DOI: 10.19428/j.cnki.sjpm.2022.21194

浙江省湖州地区就诊儿童呼吸道合胞病毒感染的流行特征

Epidemiological characteristics of respiratory syncytial virus infection among hospitalized children in Huzhou area,Zhejiang Province

  • 摘要:
    目的 了解浙江省湖州地区急性呼吸道感染儿童中呼吸道合胞病毒(RSV)的型别及流行特征。
    方法 收集2017年1月—2019年12月湖州市第一医院儿科门诊及住院的急性呼吸道感染儿童的鼻咽拭子1 856份,采用实时荧光PCR法进行RSV核酸分型(A/B型)检测,同时收集患儿的资料进行分析。
    结果 RSV总阳性率为11.1% (206/1 856),其中RSV⁃A阳性率为6.6% (123/1 856),RSV⁃B阳性率为4.5%(83/1 856)。男童RSV阳性率(13.7%)高于女童(8.3%),差异有统计学意义(P<0.01)。不同年龄组患儿的RSV阳性率随年龄增大呈下降趋势(P趋势<0.01),<1岁儿童的RSV阳性率最高(19.8%)。患儿的主要临床症状以发热和咳嗽为主。RSV阳性率以冬季最高(18.9%),夏季最低(4.2%),不同季节阳性率差异有统计学意义(P <0.01)。2017年RSV⁃B阳性率(7.6%)高于RSV⁃A阳性率(3.5%)。2018年和2019年RSV⁃A阳性率(7.7%和9.0%)分别高于RSV⁃B阳性率(2.0%和3.4%)。
    结论 湖州地区儿童急性呼吸道RSV感染A/B亚型均有流行,低龄儿童阳性率较高,在冬季集中流行,应当加强监测和防控。

     

    Abstract:
    Objective To determine the subtypes and epidemiological characteristics of respiratory syncytial virus (RSV) in children with acute respiratory infection in Huzhou area.
    Methods A total of 1 856 nasopharyngeal swabs were collected from child outpatients and inpatients in the First People’s Hospital of Huzhou from January 2017 to December 2019. RSV subtype A and B were detected by real-time fluorescence PCR. Clinical and demographic data of children were collected and analyzed.
    Results The positive rate of RSV in the collected samples was determined to be 11.1% (206/1 856), of which the positive rate of RSV-A was 6.6% (123/1 856) and that of RSV-B was 4.5% (83/1 856). The positive rate of RSV in boys was significantly higher than that in girls (13.7% vs 8.3%,P<0.01). The positive rate in different age groups showed a downward trend (P for trend <0.01), with the highest rate in children under 1 year old [19.8% (67/339)]. Common symptoms of children with RSV infection were fever and cough. The highest positive rate of RSV was 18.9% in winter, while the lowest was 4.2% in summer, demonstrating a significant seasonal pattern (P<0.01). In addition, the positive rate of RSV-B was higher in 2017 [7.6% (50/656)], and that of RSV-A was higher in 2018 and 2019 [7.7% (45/588), 9.0% (55/612)].
    Conclusion Both subtypes of RSV are prevalent in children with acute respiratory infection in Huzhou area. Positive rate of RSV is higher in young children and in winter. It warrants strengthening the disease surveillance and prevention and control measures.

     

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