Abstract: Public health is vital to the well-being of the people and to the security and stability of society.In the past three decades, the practice of public health in Shanghai was insisted on protecting the health of all citizens in the metropolis, and made brilliant achievements along with the development of the excellent global cities.The public health system in Shanghai has been gradually perfected.The city′s public health security has been increasingly consolidated.Major health status and indicators of the people in Shanghai have also been continuously improved.This paper reviews the practice and achievements of Shanghai public health system in the past thirty years.Meanwhile, it looks forward to a new chapter of building Healthy Shanghai by proposing several inspirations based on practical experience, such as strengthening system and mechanism construction, integrating clinical and preventive medicine, applying information technologies and creating health-friendly environment.