Abstract: Objective To investigate the mortality rate of skin melanoma in China to provide evidence for disease prevention and medical care. Methods Poisson regression model was used for analysis on the mortality rate of skin melanoma by means of the data from national cancer registry in China and WHO cancer center. Results The crude mortality rate of skin melanoma in China differed a lot among 41 registration areas in 2008.Studies showed it was not significantly different between male and female and was significantly lower in southwest region than those in the regions of north and northeast; and it increased with age;skin melanoma prevalence rate in China proved lower than those in Japan and South Korea. Conclusion Although the mortality rate of skin melanoma is relatively lower in China,it is worthy of further research on the risk factors(such as gender and region)and medical treatment of the disease.