王伟, 王娜, 王云辉, 朱美英, 王瑞平, 毛琦, 安娜, 刘星, 张铁军, 江峰, 赵琦, 赵根明, 姜永根. 上海某社区35~59岁高血压人群同型半胱氨酸水平及其分布特征[J]. 上海预防医学, 2018, 30(5): 340-345. DOI: 10.19428/j.cnki.sjpm.2018.18652
引用本文: 王伟, 王娜, 王云辉, 朱美英, 王瑞平, 毛琦, 安娜, 刘星, 张铁军, 江峰, 赵琦, 赵根明, 姜永根. 上海某社区35~59岁高血压人群同型半胱氨酸水平及其分布特征[J]. 上海预防医学, 2018, 30(5): 340-345. DOI: 10.19428/j.cnki.sjpm.2018.18652
shu
Wei WANG, Na WANG, Yun-hui WANG, Mei-ying ZHU, Rui-ping WANG, Qi MAO, Na AN, Xing LIU, Tie-jun ZHANG, Feng JIANG, Qi ZHAO, Gen-ming ZHAO, Yong-gen JIANG. Homocysteine levels and distribution in hypertensives aged 35-59 in a community of Shanghai[J]. Shanghai Journal of Preventive Medicine, 2018, 30(5): 340-345. DOI: 10.19428/j.cnki.sjpm.2018.18652
Citation: Wei WANG, Na WANG, Yun-hui WANG, Mei-ying ZHU, Rui-ping WANG, Qi MAO, Na AN, Xing LIU, Tie-jun ZHANG, Feng JIANG, Qi ZHAO, Gen-ming ZHAO, Yong-gen JIANG. Homocysteine levels and distribution in hypertensives aged 35-59 in a community of Shanghai[J]. Shanghai Journal of Preventive Medicine, 2018, 30(5): 340-345. DOI: 10.19428/j.cnki.sjpm.2018.18652
shu

上海某社区35~59岁高血压人群同型半胱氨酸水平及其分布特征

Homocysteine levels and distribution in hypertensives aged 35-59 in a community of Shanghai

    摘要
  • 摘要:
    目的分析上海某社区35~59岁高血压人群同型半胱氨酸(homocysteine, Hcy)水平及分布特征，了解该人群高同型半胱氨酸血症(hyperhomocysteinemia, HHcy)的患病率及其相关因素。
    方法采用整群随机抽样方法，对2016年上海某社区1 161例35~59岁高血压患者进行体格检查及问卷调查，并测定血浆Hcy水平，采用SPSS 22.0软件分析不同高血压人群Hcy水平及HHcy患病状况，采用非条件logistic回归方法分析HHcy相关危险因素。
    结果1 161例35~59岁高血压患者的Hcy中位数为14.80 μmol/L(男性：18.10 μmol/L，女性：13.70 μmol/L，P < 0.05)。Hcy水平随年龄递增，不同高血压家族史、糖尿病史、高血压组别以及体质指数(BMI)比较，男、女性Hcy中位数水平差异均有统计学意义(P < 0.05)；人群HHcy检出率为48.06%(男性72.12%，女性27.29%；χ2＝232.45，P < 0.05)。高血压组别是男性HHcy的相关因素，重点组和好转组分别是稳定组的16.94倍及4.43倍；女性重点组及好转组相应OR值(95%CI)分别为42.63(16.13, 121.94)及23.74(9.67, 61.81)；女性HHcy水平还与年龄相关，50岁以上年龄组的危险度是50岁以下组的2倍以上。
    结论Hcy性别差异明显，男性、高血压分组是35~59岁社区高血压人群HHcy的相关因素。

     

    Abstract:
    ObjectiveTo investigate homocysteine levels, its associated factors, as well as the prevalence of hyperhomocysteinemia (HHcy) in hypertension patients aged 35-59 in a community of Shanghai.
    Methods A total of 1 161 hypertension patients were recruited by using randomized cluster sampling methods.Each participant received physical tests and completed a structured questionnaire.Plasma homocysteine levels were measured while subjects were fasting.SPSS 22.0 software was used to compare both the homocysteine levels and HHcy pevalence among different groups of hypertension patients.Logistic regression models were conducted to analyze the potential risk factors.
    Results The median concentration of Hcy was 14.80 μmol/L (male:18.10μmol/L, female:13.70 μmol/L, P < 0.05).Hcy levels increased with age and differed by family hypertension history, diabetes, hypertension group, and BMI both in men and women.The prevalence rate of HHcy for all participants was 48.06% (male:72.12%, female:27.29%;χ2＝232.45, P < 0.05).Hypertension group was one of the independent risk factor and as compared with the stable group, the corresponding ORs for focus group and improved group were 16.94 and 4.43 for men, and 42.63 and 23.74 for women, respectively.The HHcy prevalence was more than twice in women aged 50 and above, as compared with that in women aged younger than 50.
    Conclusion Hcy levels show a significant gender disparity and its risk factors for community hypertension patients aged 35-59, including male and hypertension.

     

    • HTML全文
    • 参考文献(20)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回