2015-2016年上海市脊髓灰质炎疫苗免疫策略调整前后婴儿抗体水平变化

刘敏勇; 黄卓英; 陆箐; 杨建萍; 杨玉颖

doi:10.19428/j.cnki.sjpm.2020.18789

2015-2016年上海市脊髓灰质炎疫苗免疫策略调整前后婴儿抗体水平变化

Polio antibody levels in infants during 2015-2016 in Shanghai before and after polio vaccination strategy adjustment

摘要

摘要:
目的了解2016年上海市实施新的脊髓灰质炎疫苗免疫策略前后婴儿脊髓灰质炎抗体水平的变化情况, 为免疫策略的优化提供参考。
方法应用微量细胞中和实验检测上海市新的脊髓灰质炎疫苗免疫策略实施前后婴儿的抗体水平, 并比较抗体水平的变化。
结果新的脊髓灰质炎疫苗免疫策略实施前后分别检测67名和41名完成基础免疫的健康婴儿血清, 其抗体阳性率Ⅰ型、Ⅲ型均达100%。几何平均滴度(GMT)在实施前后分别为Ⅰ型1:1 047.46和1:254.70, Ⅲ型1:513.52和1:185.49。
结论上海市实施新脊髓灰质炎疫苗免疫策略后婴儿脊灰抗体水平均维持在较高水平。

Abstract:
ObjectiveTo investigate the neutralized antibody level of poliomyelitis among healthy children before and after implementation of the new immunization strategy in Shanghai.
MethodsThe poliomyelitis levels of healthy children were detected by neutralization test of the micro cells.
ResultsThe neutralizing antibody positive rates were 100% for polioⅠand polioⅢ before and after implementation of the new immunization strategy.GMTs (geometric mean titers) for polioⅠwere 1:1 047.46 before it, and 1:254.70 after it; those for polio Ⅲ were 1:513.52 before it and 1:185.49 after it.
ConclusionThe neutralized antibody levels of the poliomyelitis among healthy infants maintain a high level before and after implementing the new immunization strategy in Shanghai.

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