上海某院体检女性血清<b>25</b>羟维生素<b>D</b>与甲状腺自身抗体及甲状腺结节间的关系

吴玉梅; 高永辉

doi:10.19428/j.cnki.sjpm.2022.22149

上海某院体检女性血清25羟维生素D与甲状腺自身抗体及甲状腺结节间的关系

Association between serum 25-hydroxyvitamin D and thyroid autoantibodies and thyroid nodules in women for health examination in Shanghai

摘要

摘要:
目的研究上海某疗养院女性体检人群血清25羟维生素D［25（OH）D］水平与甲状腺自身抗体及甲状腺结节间的关系。
方法回顾性分析2 108例来院体检女性的资料，根据血清25（OH）D值分为充足组［25（OH）D≥30 μg·L^-1］、不足组［20 μg·L^-1≤25（OH）D< 30 μg·L^-1］、缺乏组［10 μg·L^-1≤25（OH）D<20 μg·L^-1］及严重缺乏组（<10 μg·L^-1）。比较各组血清 25（OH）D水平与甲状腺自身抗体及甲状腺结节间的关系。
结果 2 108例体检女性的25（OH）D缺乏率为69.31%；维生素D严重缺乏组与充足组间的碱性磷酸酶（ALP）、低密度脂蛋白（LDL）、抗甲状腺球蛋白抗体（TGAB）、抗甲状腺过氧化物酶抗体（TPOAB）水平差异有统计学意义（P<0.05）；甲状腺结节的患病率、TGAB阳性率、TGAB和（或）TPOAB阳性率在4组间差异有统计学意义（ $χ_{趋势}^{2}$ 分别为81.299、16.194、11.202，均P<0.05）。logistic回归分析显示，血清25（OH）D水平与年龄、甲状腺结节患病率、TGAB阳性率、TGAB和（或）TPOAB阳性率相关，且随着缺乏程度的加重，风险逐渐增加。
结论该疗养院体检女性维生素D缺乏率较高，血清25（OH）D不足或缺乏，与年龄、甲状腺自身抗体阳性及结节的发生相关。

Abstract:
Objective To determine the level of serum 25-hydroxyvitamin D （25（OH）D） and its association with thyroid autoantibodies and thyroid nodules in adult women for health examination in Shanghai.
Methods We recruited a total of 2 108 healthy women for examination in the hospital. According to the serum 25-hydroxyvitamin D， the women were classified into four groups： 25（OH）D≥30 μg·L^-1 as sufficient group， 20 μg·L^-1≤25（OH）D<30 μg·L^-1 as insufficient group， 10 μg·L^-1≤25（OH）D<20 μg·L^-1 as the deficiency group， and<10 μg·L^-1 as severe deficiency group. The association was determined between the serum 25（OH）D and thyroid autoantibodies and thyroid nodules.
Results The prevalence of deficiency in adult women was determined to be 69.31%. Alkaline phosphatase （ALP）， low-density lipoprotein （LDL）， anti-thyroglobulin antibodies （TGAB） and anti-thyroid peroxidase autoantibody （TPOAB） levels significantly differed between the severe deficiency group and sufficient group （each P<0.05）. Moreover， prevalence of thyroid nodules， TGAB， TGAB and/or TPOAB differed significantly across the four groups （each P<0.05）.Logistic regression analysis showed that decrease of serum 25（OH）D was significantly associated with age and increasing prevalence of thyroid nodules， TGAB， TGAB and/or TPOAB.
Conclusion Vitamin D deficiency remains high in adult women for health examination in Shanghai. Serum 25（OH）D insufficiency or deficiency is associated with age， thyroid autoantibodies and thyroid nodules.

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