Objective To analyze the morbidity and mortality characteristics and prevalence trends of asopharyngeal carcinoma among registered residents in Yuyao City of Zhejiang Province from 2012 to 2021， and to provide suggestions for the prevention and treatment of the cancer.

Methods The incidence and mortality data of asopharyngeal carcinoma in Yuyao City from 2012 to 2021 were collected. The incidence， mortality， standardized rate， cut-off rate， cumulative rate and annual percentage of trend change were calculated. A linear logarithmic model was used to analyze the variation trend.

Results From 2012 to 2021， the crude incidence rate was 6.46/10⁵ in Yuyao， while the Chinese standard rate was 4.78/10⁵ and the world standard rate was 3.68/10⁵， which all increased over the years. The indicators in males were higher than these in females （χ²=85.377， P<0.01）. The cumulative incidence rate of ≥65 years old group was the highest （13.63/10⁵）. The crude mortality rate was 2.45/10⁵， while the Chinese standardized rate was 1.47/10⁵ and the world standard rate was 1.14/10⁵. The crude mortality rate in males was 3.25/10⁵，which was higher than females（1.68/10⁵）（χ²=20.958， P<0.01）. Overall， the cumulative rate was highest reached its peak in ≥75 years old group （10.75/10⁵）. The male mortality rate reached its peak in the ≥80-year-old population （12.36/10⁵）， and the female mortality rate in ≥75 years old group （11.03/10⁵）.

Conclusion The incidence rate of asopharyngeal carcinoma in Yuyao City is generally increasing， but the mortality rate has no obvious variation. The key population for prevention and treatment in Yuyao City is male， middle-aged and elderly.