宁晨曦, 张诗琦, 吴哲渊, 陈静, 张祖荣, 沈鑫, 袁政安. 上海市耐多药肺结核患者治疗结局相关因素研究[J]. 上海预防医学, 2023, 35(3): 219-223. DOI: 10.19428/j.cnki.sjpm.2023.22404
引用本文: 宁晨曦, 张诗琦, 吴哲渊, 陈静, 张祖荣, 沈鑫, 袁政安. 上海市耐多药肺结核患者治疗结局相关因素研究[J]. 上海预防医学, 2023, 35(3): 219-223. DOI: 10.19428/j.cnki.sjpm.2023.22404
shu
NING Chenxi, ZHANG Shiqi, WU Zheyuan, CHEN Jing, ZHANG Zurong, SHEN Xin, YUAN Zheng'an. Study on treatment outcome and risk factors of multidrug-resistant pulmonary tuberculosis patients in Shanghai[J]. Shanghai Journal of Preventive Medicine, 2023, 35(3): 219-223. DOI: 10.19428/j.cnki.sjpm.2023.22404
Citation: NING Chenxi, ZHANG Shiqi, WU Zheyuan, CHEN Jing, ZHANG Zurong, SHEN Xin, YUAN Zheng'an. Study on treatment outcome and risk factors of multidrug-resistant pulmonary tuberculosis patients in Shanghai[J]. Shanghai Journal of Preventive Medicine, 2023, 35(3): 219-223. DOI: 10.19428/j.cnki.sjpm.2023.22404
shu

上海市耐多药肺结核患者治疗结局相关因素研究

Study on treatment outcome and risk factors of multidrug-resistant pulmonary tuberculosis patients in Shanghai

    摘要
  • 摘要:
    目的 了解上海市2017—2018年纳入二线治疗的耐多药肺结核（MDR⁃TB）患者的治疗结局特征，分析影响其治疗结局的因素。
    方法 利用中国结核病管理信息系统、医院电子病历信息系统、全基因组测序结果及问卷调查收集的数据，对182例MDR⁃TB患者进行治疗结局特征描述，应用logistic回归分析影响治疗成功与否的因素。
    结果 182例MDR⁃TB患者的治疗成功率为65.4%，失访率为8.2%，死亡率为4.9%，无法评估率为13.7%，停药率为7.7%。影响MDR⁃TB患者治疗成功与否的因素包含年龄35~岁（OR=5.28，95%CI：1.58~17.59，P=0.007）、55~岁（OR=16.30，95%CI：4.36~60.92，P<0.001）和治疗依从性（OR=0.55，95%CI：0.42~0.72，P<0.001）。
    结论 2017—2018年上海市MDR⁃TB患者治疗成功率高于国内平均水平，年龄越大、治疗依从性越差的患者出现不良治疗结局的风险越大。

     

    Abstract:
    Objective To describe the characteristics of treatment outcomes of multidrug-resistant tuberculosis （MDR-TB） patients enrolled in second-line treatment in Shanghai from 2017 to 2018， and to analyze the influencing factors of treatment outcomes.
    Methods Totally 182 MDR-TB patients were analyzed by using data collected from the China tuberculosis management information system， the hospital's electronic medical record information system， whole genome sequencing results and a questionnaire survey， and logistic regression analysis was used to analyze the factors affecting the success of treatment.
    Results In 182 MDR-TB patients， the success rate of treatment was 65.4%， the loss to follow-up rate was 8.2%， the mortality rate was 4.9%， the unassessable rate was 13.7%， and the drug withdrawal rate was 7.7%. The factors affecting the success of treatment in MDR-TB patients included age （35‒ years old， OR=5.28， 95%CI： 1.58‒17.59， P=0.007； 55‒ years old， OR=16.30， 95%CI： 4.36‒60.92， P<0.001） and compliance to medication （OR=0.55， 95%CI： 0.42‒0.72， P<0.001）.
    Conclusion The treatment success rate of MDR-TB patients in Shanghai from 2017 to 2018 is significantly higher than the average level in China. Older patients and patients with less compliant are at higher risk of adverse treatment outcomes.

     

    • HTML全文
    • 参考文献(17)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回