黄俊雄, 陶一敏, 钟佩, 赵春青, 李晓光, 王慧. 高通量多肽芯片及其应用[J]. 上海预防医学, 2023, 35(1): 66-69. DOI: 10.19428/j.cnki.sjpm.2023.22753
引用本文: 黄俊雄, 陶一敏, 钟佩, 赵春青, 李晓光, 王慧. 高通量多肽芯片及其应用[J]. 上海预防医学, 2023, 35(1): 66-69. DOI: 10.19428/j.cnki.sjpm.2023.22753
HUANG Junxiong, TAO Yimin, ZHONG Pei, ZHAO Chunqing, LI Xiaoguang, WANG Hui. Review on data analysis and application of high-throughput peptide arrays[J]. Shanghai Journal of Preventive Medicine, 2023, 35(1): 66-69. DOI: 10.19428/j.cnki.sjpm.2023.22753
Citation: HUANG Junxiong, TAO Yimin, ZHONG Pei, ZHAO Chunqing, LI Xiaoguang, WANG Hui. Review on data analysis and application of high-throughput peptide arrays[J]. Shanghai Journal of Preventive Medicine, 2023, 35(1): 66-69. DOI: 10.19428/j.cnki.sjpm.2023.22753

高通量多肽芯片及其应用

Review on data analysis and application of high-throughput peptide arrays

  • 摘要: 本文介绍一种高通量分子筛选芯片——多肽芯片。多肽芯片作为生物芯片的一种,相比其他生物芯片,有着易于制造合成、探针性质稳定、芯片探针通量高及信号特异性强等特点。针对其高通量数据的特点,研究人员提出系列深度学习、生物信息学分析算法以挖掘多肽探针与目标分子的结合规律。利用这些算法,可以实现对多肽芯片上的蛋白质靶标的结合模式、多肽与蛋白质的结合力等进行准确预测。此外,多肽芯片技术可用于研究蛋白质-蛋白质相互作用、筛选新型药物肽、疾病鉴别诊断和健康评估等方面,以上新技术的应用为公共健康研究提供创新思路。

     

    Abstract: This article introduces a high-throughput molecular screening chip: peptide arrays. As a kind of biochip, the peptide arrays are easy to synthesis, stable in probe chemistry, high-throughput in screening and highly specific compared with other biochips. To analyze the new high-throughput data, researchers have recently proposed a series of deep learning and bioinformatics methods to study the binding characteristics of peptide probes and target molecules. Those algorithms could be used to predict the binding affinity of protein targets against peptides. Moreover, peptide arrays could also play important roles in analyzing protein-protein interactions,screening novel drug peptides, disease diagnosis and general health assessment based on recent reports. The application of this new technology could provide novel insights into public health research.

     

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