吴琳媖，冯超，汪国权，等.生活饮用水中新兴污染物高分辨质谱非靶向筛查［J］.上海预防医学，2023，35（12）：1246-1252.. doi: 10.19428/j.cnki.sjpm.2023.23043
引用本文: 吴琳媖，冯超，汪国权，等.生活饮用水中新兴污染物高分辨质谱非靶向筛查［J］.上海预防医学，2023，35（12）：1246-1252.. doi: 10.19428/j.cnki.sjpm.2023.23043
shu
WU Linying,FENG Chao,WANG Guoquan,et al.Non-targeted screening of emerging contaminants in drinking water based on high-resolution mass spectrometry[J].Shanghai Journal of Preventive Medicine,2023,35(12):1246-1252.. doi: 10.19428/j.cnki.sjpm.2023.23043
Citation: WU Linying,FENG Chao,WANG Guoquan,et al.Non-targeted screening of emerging contaminants in drinking water based on high-resolution mass spectrometry[J].Shanghai Journal of Preventive Medicine,2023,35(12):1246-1252.. doi: 10.19428/j.cnki.sjpm.2023.23043
shu

生活饮用水中新兴污染物高分辨质谱非靶向筛查

Non-targeted screening of emerging contaminants in drinking water based on high-resolution mass spectrometry

    摘要
  • 摘要:
    目的 建立一种基于高分辨质谱技术的生活饮用水中新兴污染物的非靶向筛查方法并运用于实际水样。
    方法 采集上海市3个水源地水库共9个生活饮用水样，经HLB固相萃取柱净化浓缩，用液相色谱高分辨质谱仪和气相色谱高分辨质谱仪分离检测。结合mzCloud、NIST等数据库，使用Thermo Tracefinder、Excel等软件进行数据分析，用代表性化合物标准品进行方法学验证，并以农药和全氟化合物为例，分析其污染现状。
    结果 建立了一种基于液相色谱和气相色谱串接高分辨质谱技术的非靶向分析策略，在9个生活饮用水中共筛查鉴定出20种农药和4种全氟化合物。上海市黄浦江水源的农药和全氟化合物污染程度高于长江口水源。
    结论 建立的高分辨质谱非靶向筛查方法，能够不依赖标准品而检测出生活饮用水中潜在新兴污染物，为水质监管和风险评估提供了有力的技术手段。

     

    Abstract:
    Objective To establish a non-targeted screening method for emerging contaminants in drinking water based on high-resolution mass spectrometry and apply it to actual water samples.
    Methods A total of 9 drinking water samples collected from 3 reservoirs in Shanghai were purified and concentrated by HLB solid phase extraction column， then separated and analyzed by liquid chromatography high-resolution mass spectrometer and gas chromatography high⁃resolution mass spectrometer. The acquired data were analyzed by Thermo Tracefinder， Excel and other software combined with mzCloud and NIST databases. The methodology was verified with representative compound standards. Pesticide and perfluorinated compounds were taken as examples to analyze their pollution status.
    Results A non-targeted analysis strategy based on liquid chromatography and gas chromatography tandem high-resolution mass spectrometry was established. The pollution level of 20 kinds of pesticides and 4 kinds of perfluorinated compounds identified in 9 drinking water samples were higher in the Huangpu River than in the Yangtze River estuary.
    Conclusion The established non-targeted screening method by high-resolution mass spectrometry can detect potential emerging contaminants in drinking water without relying on the standards， which provides a powerful technical means for water quality monitoring and risk assessment.

     

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