Abstract: Objective To observe the effect of kaolin and propranolol on paraquat(PQ) concentration in the lungs of poisoned mice. Methods A group of 144 ICR mice were randomly divided into 3 groups:PQ, treatment, and control. Then 100 mg/kg PQ were intragastrically administrated(ig) in PQ group and treatment group, while only the same volume normal saline was given in control group. And then 48 g/kg kaolin combined with 3.2 mg/kg propranolol were administered in treatment group immediately after poisoning while only the same volume of normal saline was given in the other two groups. Pathological examination was done and PQ concentration in lungs of the mice detected 0.5 h, 1 h, 2 h, 4 h, 6 h, 8 h, 12 h, 24 h after poisoning. Results In the lungs of the mice in PQ group occurred alveolar capillary expansion, endothelial cell swelling, small or large sheet-shaped inflammation cell infiltration and mainly neutrophils while in treatment group the above lesions were apparently alleviated. In PQ and treatment groups, PQ concentration in lungs of both groups rose significantly 0.5 h after poisoning and up to peak at 4 h. But PQ concentration in lungs decreased significantly in treatment group from 4 h to 24 h after poisoning (P<0.05), as compared with that in PQ group. Conclusion PQ concentration in lungs of the poisoned mice was decreased and the injury alleviated when they were treated with kaolin combined with propranolol. It is held that further research is worth doing in clinical practice.