Abstract: Objective To explore influence factors related to job satisfaction among professionals of mental health centers in Shanghai. Methods Stratified random sampling method was designed for investigation of professionals of two mental health centers in Shanghai City.By using job satisfaction scale, emotional coping scale, emotion work questionnaire and perceived organizational support scale, data were collected and analyzed by SPSS statistical software. Results there was significant correlation between job satisfaction and emotional response, as deep acting, opinion on the status quo of their organization and perspective on the work situation (P<0.05).The correlation coefficients between job satisfaction and the latter were 0.313-0.594 (P<0.01).Surface acting was a dangerous factor to job satisfaction.On the contrary, deep acting, opinion on the status quo of their organization and outlook on the work situation were 3 protective factors for job satisfaction, of which the opinion on the status quo of their organization was of the greatest influence on job satisfaction. Conclusion The job satisfaction for professionals of mental health centers can be improved when they use more deep acting in emotion work and have more positive emotion understanding in addition to the managers providing organizational support for the staff.