Abstract: Objective To evaluate the range of vaccination age for hand-foot and mouth disease (HFMD). Methods HFMD data in 2010-2012 were obtained from Yinzhou District as the model for analysis of HFMD's age distribution characteristics, especially of severe and death cases. Logistic regression method was used to calculate the relative risk values of age groups from 0 to 11 months of age. Results In our investigation, 95.66% of cases were distributed between 0-5 years. Average incidence of HFMD for different age groups, 0-4 years old was 44.57/1000, 5 years old 9.79/1000, 6 years old 6.84/1000, and average incidence no more than 3/1000 after 7 years of age. Average incidence for death and severe cases was 22 months of age. The risk of HEMD started to greatly increase with age from 0 to 11 months old, and became much more dangerous after 10 months of age. Conclusion The initial vaccination age for HEMD should be between 6 to 10 months of age, the appropriate crowd for HFMD vaccination between 6 to 71 months of age, and vaccination is not of much significance for children after 71 months (6 years) of age.