Abstract: Objective To explore the relation between treatment outcomes in acute phase and possible influential factors of ischemic stroke. Methods We studied 109 consecutive in-hospital patients admitted by neurology department within the first 24 hours of onset from January 2012 to August 2012.The treatment outcomes after two weeks were divided into five groups according to the National Institutes of Health Stroke Scale(NIHSS). The influential factors were analyzed by monovariate and bivariate regression analysis. Results Monovariate and bivariate regression analysis showed that unfavourable outcomes were associated with high NIHSS(>10) and early use of antihypertensive drugs(OR=4.406,95%CI:1.84-10.53).And its correlation with the use of calcium antagonists(CCB) was more significant than angiotensin converting enzyme inhibitors(ACEI) and/or angiotensin receptor blocker(ARB)(P=0.001,0.169). Conclusion NIHSS>10 predicts poor outcomes of treatment in the acute phase of ischemic stroke and we should avoid using antihypertensive drugs, especially CCB, within the first 72 hours of onset.