Abstract: Objective To analyze the clinical effect and value of Buchang Wenxin Granule Combined with small dose of amiodarone for patients with ventricular arrhythmias. Methods A total of 114 cases of ventricular arrhythmias treated in our hospital in recent two years were selected as research objects. They were randomly divided into two groups:control and observation. The control group was treated with small-dose amiodarone, and the observation group, with Buchang Wenxin Granule combined with small dose of amiodarone. Their changes of QT interval and the level of hs-CRP in serum before and after treatment were recorded, as well as therapeutic effect and adverse reactions. Results Before treatment, there was no significant difference between QT interval and the level of hs-CRP in serum of the two groups, but after treatment, the QT interval in observation group was (451±52) ms, which was significantly higher than (414±46) ms in control group. And the hs-CRP levels in observation group was (2.97±1.01) mg/L, which was significantly lower than (3.56±1.05) mg/L in control group. The differences between the two groups were statistically significant (P<0.05). The ventricular arrhythmia control rate in observation group was 91.23% (52/57), which was significantly higher as compared to 73.68% (42/57) in the control group. The differences showed statistical significance (P<0.05). Adverse reaction rate in observation group was 5.26% (3/57), which was close to 7.02% (4/57) in the control group. The difference showed no significance (P>0.05). Conclusion Buchang Wenxin Granule combined with small dose of amiodarone in the treatment of ventricular arrhythmia showed great clinical curative effect, less adverse reaction, and high security.