Multivariate factors affect the influence of PM_2.5 on acute exacerbation of COPD in Shanghai

ObjectiveTo explore the relationship between acute exacerbation of COPD(AECOPD) and their clinical and living environment.

MethodsA total of 352 AECOPD patients were enrolled in the study. The co-relationship between PM_2.5 concentration, clinical and living environment and AECOPD occurrence were analyzed.

ResultsThe higher PM_2.5 concentration, the more AECOPD episodes occurred, which were related with clinical factors including age, sex, BMI, smoking history, FEV₁% and living environment including average living space, building floor and distance to main road. Clinical and living factors were analyzed by using multivariate logistic regression to form a predictive model.

ConclusionsExposure to high concentration of PM_2.5 increases the risk of developing AECOPD. The predictive model is expected to improve the early prevention of AECOPD.