ObjectiveTo investigate homocysteine levels, its associated factors, as well as the prevalence of hyperhomocysteinemia (HHcy) in hypertension patients aged 35-59 in a community of Shanghai.
Methods A total of 1 161 hypertension patients were recruited by using randomized cluster sampling methods.Each participant received physical tests and completed a structured questionnaire.Plasma homocysteine levels were measured while subjects were fasting.SPSS 22.0 software was used to compare both the homocysteine levels and HHcy pevalence among different groups of hypertension patients.Logistic regression models were conducted to analyze the potential risk factors.
Results The median concentration of Hcy was 14.80 μmol/L (male:18.10μmol/L, female:13.70 μmol/L, P < 0.05).Hcy levels increased with age and differed by family hypertension history, diabetes, hypertension group, and BMI both in men and women.The prevalence rate of HHcy for all participants was 48.06% (male:72.12%, female:27.29%;χ2＝232.45, P < 0.05).Hypertension group was one of the independent risk factor and as compared with the stable group, the corresponding ORs for focus group and improved group were 16.94 and 4.43 for men, and 42.63 and 23.74 for women, respectively.The HHcy prevalence was more than twice in women aged 50 and above, as compared with that in women aged younger than 50.
Conclusion Hcy levels show a significant gender disparity and its risk factors for community hypertension patients aged 35-59, including male and hypertension.
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