Association between dietary cruciferous vegetables, urinary isothiocyanates level and gastric cancer risk in men:A nested case-control study

ObjectiveTo explore the association between intake of cruciferous vegetables (CV), level of urinary isothiocyanates (ITC) and the risk of male gastric cancer in urban Shanghai.

MethodsA nested case-control study was conducted within the Shanghai Men′s Health Study.Incident gastric cancer cases (N=291) were diagnosed prior to December 31, 2010.With a 2 ︰ 1 control to case ratio, 582 controls were selected from cohort members.Dietary CV consumption was calculated using a food-frequency questionnaire.Urinary ITC level was measured by the high performance liquid chromatography method.Unconditional logistic regression model was used to evaluate the relationship of CV intake and ITC level with the risk of male gastric cancer.

ResultsNeither the dietary CV intake nor urinary ITC level differed significantly between cases and controls.Categorical data analysis based on tertiles of controls also showed no significant association between them.Compared to the lowest tertile, the OR(95%CI) for the second and third tertile of urinary ITC level were 0.94 (0.66－1.34) and 1.01 (0.71－1.43), respectively, after adjustment for age, smoking, alcohol consumption and chronic stomach diseases.Similar analyses for dietary CV intake showed null association.

ConclusionCruciferous vegetables intake and urinary isothiocyanates level were not associated with risk of gastric cancer among men in urban Shanghai.