Drug resistance analysis on 626 cases of pulmonary tuberculosis in Jiangshan City, Zhejiang Province

ObjectiveTo investigate the drug resistance of pulmonary tuberculosis and provide scientific basis for clinical formulation of chemotherapy regimens.

MethodsA retrospective analysis of cases of tuberculosis in hospitals in Jiangshan City from January 2011 to July 2015 was conducted to test the resistance of six anti-TB drugs.

ResultsA total of 626 patients with drug sensitivity were included in this study, of whom 584 were initially treated and 42 retreated; 165 were drug resistant; the total drug resistance rate was 26.4%, the monoresistance rate 15.7%, polyresistance rate 5.3% and multidrug resistance rate 5.4%.The total resistance rate in the newly diagnosed patients was 24.5%.The monoresistance rate was 15.9%, polyresistance rate 5.1%, and multidrug resistance rate 3.4%.The total drug resistance rate in retreated patients was 52.4%, monoresistance rate 11.9%, polyresistance rate 7.1%, and multidrug resistance rate 33.3%.The resistance rates of newly diagnosed patients and retreated patients were isoniazid (INH)13.7%, 42.9%;rifampicin (RFP) 4.3%, 33.3%;ethambutol (EMB) 2.7%, 7.1%;Strain (SM) 13.4%, 33.3%;Ofloxacin 6.2%, 19.0%;Kanamycin (KM) 2.9%, 11.9%.

ConclusionThe resistance rate in retreated pulmonary tuberculosis patients in Jiangshan is high, especially the multidrug resistance rate.The newly-treated patients has higher resistance to isoniazid and streptomycin, and the initially treated and retreated patients prove to have lower resistance to ethambutol.Rational use of anti-tuberculosis drugs should be based on the detection of drug resistance in the local region so as to improve efficacy and strengthen integrated managementoftuberculosis.