Effect observation on senile inoculation of 23-valent pneumococcal polysaccharide vaccine in Baoshan District of Shanghai City

ObjectiveTo evaluate the effectiveness of 23-valent pneumococcal polysaccharide vaccine(PPV23) inoculated among people over 60 years old.

MethodsFrom 13 villages/committees of 6 among 17 communities in Baoshan District of Shanghai were drawn 950 vaccinated and 1 000 unvaccinated objects in April -June 2014. Through cohort study were investigated the situation of the use of antibiotics and the incidence of pneumonia and other respiratory disease during one year after inoculation of PPV23.

ResultsBy tendencies score matching method were matched the objects. Finally, there were 875 cases in both vaccinated and unvaccinated groups. After one year of follow-up, the pneumonia incidence in vaccination and unvaccinated groups were 0.91% and 3.43%, and the difference between the two groups was statistically significant(χ²=13.020, P < 0.01). The vaccine efficacy of PPV23 was 73.47%. The acute bronchitis incidences of the two groups were 2.40% and 7.89% respectively, whose difference was of statistical significance(χ²=26.988, P < 0.01), with the vaccine efficacy being 69.71%. And the acute exacerbation rate of chronic bronchitis were 0.11% and 1.60%, whose difference was statistically significant(χ²=11.364, P < 0.01), with vaccine efficacy being 93.13%. The incidences of upper respiratory tract infection were 18.63% and 27.43% respectively, the difference being statistically significant (χ²=19.114, P < 0.01). The usage rates of antibiotics in the two groups were 4.46% and 19.29%, the difference being statistically significant(χ²=21.767, P < 0.01).

ConclusionPPV23 vaccination can reduce risks of pneumonia and other respiratory tract infection for elderly people, and reduce usage rate of antibiotics.