ObjectiveTo observe the effect of synbiotics in alleviating chemotherapy-related toxic and side effects and enhancing the effect of post-operative chemotherapy.
MethodsA total of 40 postoperative colorectal cancer patients who received XELOX chemotherapy (oxaliplatin + capecitabine) in Shanghai Tenth People′s Hospital from June 2017 to September 2018 were selected and randomly divided into the synbiotics group and placebo group.The synbiotics group took synbiotics preparations orally for 2 months, while the placebo group took placebo orally for 2 months.Clinical follow-up visits and clinical test results were collected before the first chemotherapy and 2 months after the intervention.
ResultsChemotherapy-associated diarrhea (CID) occurred in 2 patients in the synbiotics group, compared with 9 patients in the placebo group, showing a statistically significant difference (P=0.013).Clinical follow-up results showed that 2 patients in the synbiotics group had decreased appetite, 3 patients had nausea and vomiting, and 17 and 10 patients in the placebo group, respectively.The incidence of decreased appetite and nausea and vomiting was significantly reduced in the synbiotics group, and the difference between the groups was statistically significant (P < 0.001, P=0.018).There was no significant difference between the two groups in constipation, abdominal pain, bone marrow suppression, increased tumor markers, and fecal occult blood (P>0.05).The results of pre-albumin, albumin, aspartate transaminase (AST) and CD4/CD8 in the synbiotics group were all better than those in the placebo group (P < 0.001, P=0.006, P=0.035, P=0.043).There was no statistical difference in other clinical indicators (P>0.05).During the treatment, no adverse reactions related to synbiotics were observed in the patients.
ConclusionSynbiotics can improve the toxic and side effects of postoperative chemotherapy for colorectal cancer and improve the quality of life for patients undergoing chemotherapy.
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