Relationship between serum uric acid level and prognosis of stroke

ObjectiveTo investigate the correlation between serum uric acid levels and acute stroke, its incidence and prognosis.

MethodsFrom January 2015 to January 2017 in Changhai Community Health Service Centers, a series of 287 hospitalized patients first diagnosed with acute stroke were as the case group, of whom 160 were with cerebral infarction(CI group), and 117 with intracerebral hemorrhage(brain hemorrhage). Their concentration of serum lipids, uric acid and other biochemical indicators were measured in comparison with those of 100 healthy people(control group), and the relationship was analyzed between uric acid levels and the occurrence of stroke, and between uric acid levels and the oxidized low density lipoprotein in cerebral infarction. All above stroke patients were scored with discharge modified Rankin scale, for investigation of the relationship between serum uric acid concentration and stroke prognosis.

ResultsSerum uric acid concentration in infarction was significantly lower than that in the control group; uric acid levels in male patients with cerebral infarction was lower than those in the control group, the difference being statistically significant(P < 0.05). But in female patients, the difference in uric acid was not of statistical significance as compared with that of the control group. Uric acid level in high age patients with cerebral infarction was lower than the control group, while uric acid level in the low age group was slightly lower than that in the control group, but the difference was not statistically significant; uric acid concentrations in patients with cerebral hemorrhage was lower than those in the healthy control group, the difference being existant in both sex and age(P < 0.01);discharge score for all stroke patients showed that the higher the levels of uric acid was found in patients with cerebral infarction, the better was the prognosis, and the worse was the prognosis if patients' uric acid levels were lower. Uric acid levels(P < 0.01)in patients with intracerebral hemorrhage showed this trend too.(P=0.05).

ConclusionSerum uric acid levels are decreased in cerebral infarction and cerebral hemorrhage and may be a useful prognostic indicator for stroke patients.