Expression and relationship of AQP1 and AQP5 in different cervical epithelial lesions

Objective To investigate the expression and relationship of aquaporin1(AQP1) and aquaporin5(AQP5) in different cervical epithelial lesions.Methods The expression of AQP1 and AQP5 in 43 samples of cervical squamous cell carcinoma, 49 samples of cervical intraepithelial neoplasia(CIN) and 21 samples of normal cervical tissue were assessed by using immunohistochemical method, and correlation between them were analyzed.Results The positive rate of AQP1 in the cervical squamous cell carcinoma and CIN were 90.70% and 77.55%, respectively, the positive rate of AQP1 was 42.86% in the normal cervical tissue, the expression of AQP1 in the cervical squamous cell carcinoma and CIN were significantly higher than normal cervical (P<0.01); the expression of AQP1 had no difference in the cervical squamous cell carcinoma and CIN (P>0.05); the positive rate of AQP1 was 80.00% and 75.86% in the low-grade squamous intrepthelial lesions(LSIL) and high-grade squamous intrepthelial lesions(HSIL), the expression of AQP1 in LSIL and HSIL were no difference(P>0.05); the expression of AQP1 in cervical squamous cell carcinoma had no association with tissue differentiation and age (P>0.05); the positive rate of AQP5 was 74.40% in the cervical squamous cell carcinoma, the positive rate of AQP5 were 53.06% in the CIN and 14.29% in normal cervical tissue, the expression of AQP5 in the cervical squamous cell carcinoma was significantly higher than CIN and normal cervical (P<0.05, P< 0.01),the expression of AQP5 in the CIN was significantly higher than normal cervical (P<0.01); the expression of AQP5 had no difference in LSIL and HSIL (P>0.05); the expression of AQP5 in cervical squamous cell carcinoma had no association with tissue differentiation and age (P>0.05); there was no correlation between AQP1 and AQP5 expression in tumor tissues (P>0.05).Conclusion Over expression of AQP1 and AQP5 in the cervical squamous cell carcinoma and CIN play important roles in carcinogenesis and progression of cervical squamous cell carcinomas through increasing permeable transport of water in vascular endothelium cells and tumor cells respectively.