ObjectiveTo ascertain the clinical characteristics and correlative factors of drug-induced liver injury caused by anti-tuberculosis drugs and explore the possible causes.
MethodsA retrospective review was made on anti-tuberculosis drug-induced liver injury treated in Shanghai Public Health Clinical Center during 2016, focusing on demographic information, clinical data, and laboratory data. Comparisons among groups were made with t-test, Mann-Whitney test, and Fisher's exact test. Risk factors were analyzed with multivariate logistic regression.
ResultsForty-eight patients were enrolled in the study, including eighteen drug-induced liver injury (DILI) cases and thirty controlled cases, who received anti-tuberculosis treatment. The average onset age was (36.65±21.62)years old. Among eighteen DILI cases, 72.22% were cholestatic, 5.56% hepatocellular injury, and the rest were the mixed type. Half of the DILI cases were severe ones. There were more INH+EMB combinations in DILI groups (16.67% vs 0, P=0.05). Multivariate logistic regression showed that age and gender were correlative factors of DILI (OR=50.04, 95%CI: 1.35~1 852.83, P=0.03;OR=128.36, 95%可信区间1.33~12 347.14, P=0.04) and those with higher baseline IgG level were more likely to have DILI (OR=26.38, 95%CI:0.99~706.25, P=0.05).
ConclusionAge and gender were correlative factors of DILI and baseline IgG level probably was a correlative factor.
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