Correlation between multiple HPV infection and cervical lesions

ObjectiveTo investigate the relationship between multiple infection of human papilloma virus (HPV) and cervical lesions.

MethodsThe cervical cell specimens of 115 463 women from January 2013 to December 2016 in Minhang District were examined by using the method of bar smear combined with HPV genotyping, and diagnosis of cervical lesions done according to histopathology.The proportion and genotype distribution of HPV multiple infection in different types of cervical lesions were compared.

ResultsThe HPV infection rate was 11.18% and the high risk HPV infection rate was 10.93%.The multiple infection rate was 21.02%, the double infection was the most common and the most subtype was six infection.The infection rate of HPV in 604 patients with cervical lesions was 94.21%, all of them were high risk type.The multiple infection rate was 23.73%, the double infection was the most common, and the most subtype was four infection.There was no significant difference in the incidence of cervical lesions/carcinogenesis between multiple HPV infection and single HPV infection(P > 0.05).With the increase of the infection subtype, the number of cases of cervical lesions tended to decrease, and the higher the level of the lesion was, the more obvious it was.The multiple HPV infection rate cervical squamous cell carcinoma group was only 15.69%.Compared with LSIL group and HSIL group, the multiple infection rate of HPV had statistical significance(P < 0.05).The HPV single infection subtype of cervical lesions located in the first five was HPV16, 52, 58, 18, 33 type, of which type HPV16 was 38.71%.Multiple infections were mainly combined with HPV16-type infection, accounting for 56.30%, and cervical squamous cell carcinoma accounting for 100%.

ConclusionMultiple HPV infection does not increase the chance of cervical lesions.The severity of cervical lesions is not related to the number of HPV infection types, but to the genotype of infected HPV.The carcino-genicity of type HPV16 is the strongest.After the census, close follow-up and management are required of type HPV16, especially those containing HPV16 type multiple persistent infection.