ObjectiveTo ascertain the drug resistance for pulmonary tuberculosis in Taizhou City, and to provide basis for tuberculosis prevention and control strategy.
MethodsThe sputum samples were collected form 267 smear positive pulmonary tuberculosis patients who registered in a drug susceptibility testing (DST) monitoring site in Taizhou City form 2015 to 2017.Then with culture, identification of Mycobacterium and DST for 9 anti-tuberculosis drugs isoniazid (INH), rifampicin (RFP), ethambutanol (EMB), streptomycin(SM), kanamycin (KAM), ofloxacin (OFX), crinkledmycin (CPM), promethylamine (PTO) and para amino salicylate (PAS) by using proportion method performed on all sputum specimens.
ResultsOf the 267 smear positive cases, 220 were cultured with 190 culture positive (17 were identified as nontuberculous mycobacterial infections), 28 culture negative, and 2 contaminated.Among 160 cases with the result of DST to 9 drugs, the overall drug resistance rate was 22.5%.The overall drug resistance rates were 21.4% and 33.3% in the newly diagnosed patients and retreated patients respectively.There was no significant difference between the two groups (P>0.05).The multidrug resistance rate was 3.1%, and had a significant difference between the new and retreated patients (0.7% vs.26.7%, P < 0.01).Drug resistances rates of the 9 drugs ranged from high to low as: INH (8.1%), PTO (8.1%), SM (6.9%), RFP (6.3%), OFX (2.5%), PAS (2.5%), EMB (2.5%), CPM (2.5%) and KAM (2.5%).There was no gender difference found in drug resistance rates (P>0.05).Neither was there age difference (P>0.05).
ConclusionThe epidemic of drug-resistant of tuberculosis in Taizhou City are still high, especially that of acquired multi-drug resistance of tuberculosis.We must continue to improve the "three-in-one" management model, improve the quality of clinical diagnosis and treatment, and strengthen community medication management.
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