Mother-to-child transmission of hepatitis B virus and its influencing factors in 234 HBsAg positive parturients

ObjectiveTo study the transmission of hepatitis B virus (HBV) from mother to child and the related impact factors.

MethodsAn epidemiological questionnaire was conducted on 234 participants with positive HBsAg from Shanghai Pudong Health Care Hospital for Women and Children.Bloods samples were collected to detect the markers and DNA titer of HBV.HBsAg positiveness and HBV DNA positiveness in umbilical cord blood was defined as neonatal HBV positiveness.A series of 65 newborn babies were followed up from birth to 7 months, and the collection of blood samples and the detection of the markers and DNA titer of HBV were performed.

ResultsThe positive rate of intrauterine HBV was 7.7%.Maternal HBeAg positivity and high concentration of HBV DNA were the influencing factors of HBV mother-to-child transmission.The immune failure rate of hepatitis B vaccine after 7 months of newborns was 1.5%.

ConclusionIt is imperative to strengthen pregnancy management for maternal with positive HBsAg, positive HBeAg, and high concentration of HBV DNA, carrying out treatment and intervention of HBV infection.For HBsAg positive maternal newborns should be done active and passive immunization within 24h, so as to reduce the risk of HBV infection in infants.