Susceptibility factors of multi-drug-resistant bacteria in community and nosocomial infections in Pudong New Area of Shanghai

ObjectiveTo explore the susceptibility factors of multi-drug resistant bacteria, and compare the similarities and differences of susceptibility factors between community infection and nosocomial infection, providing basis for scientific prevention and control of multi-drug resistant bacterial infection.

MethodsA case-control study was conducted.For the study groups, we selected randomly 120 cases of multi-drug-resistant bacteria infection from communities and another 120 cases from hospitals, then according to the principle of comparability, the control groups were selected by the ratio of 1 : 2(control group 1 and control group 2).The investigation included the causes of host itself, iatrogenic factors, environmental factors and so on.

ResultsThere was no significant difference in age, sex and type of residence between nosocomial infection and control groups, community infection and control groups (P>0.05).After adjusting the related factors, it was found that hypoproteinemia before infection, high or low leucocyte count before infection, multiple drug-resistant bacteria cases in the same ward, and taking antibiotics in case of illness were the causes of multiple drug resistance from nosocomial infection, the OR values and 95% confidence intervals were 4.009 (2.232-7.203), 4.200 (1.486-11.869), 4.725 (2.918-7.651), 3.844 (1.644-8.987) and 2.786 (1.359-5.714) respectively.High leucocyte count before infection and taking antibiotics for sickness were risk factors for community infection with multi-drug-resistant bacteria, the OR value and 95% confidence interval were 4.290 (1.646-11.178) and 5.539 (2.090-14.678) respectively.

ConclusionGood control of protein level, leucocyte level, early warning and disposal of multi-drug-resistant bacteria cases, and rational use of antibiotics are effective measures to reduce the infection of multi-drug-resistant bacteria.