Advantages of COVID-19 vaccine in the T cell immune response

Objective To illustrate the mechanism of COVID-19 vaccine in the T cell immune response.

Methods Based on the characteristics of T cell and B cell immune response， we matched the data of incubation periods across the SARS-CoV-2 prototype strain， Delta variants， and Omicron variants and effectiveness of mRNA and inactivated COVID-19 vaccines for analysis.

Results The effectiveness of mRNA COVID-19 vaccine against infection and onset was consistent with incubation period principally being ≥5 days. In contrast， the effectiveness of inactivated COVID-19 vaccine was consistent with incubation period principally being ≥8 days.

Conclusion It may be interpreted by faster T cell immune response stimulated by mRNA vaccine， compared to B cell immune response by inactivated vaccine.