Relationship investigated between ambulatory arterial stiffness index and target organ damage in elderly hypertensive patients according to the dipper form of their dynamic blood pressure

Objective To investigate the associations of ambulatory arterial stiffness index(AASI) with target organ damage(TODs) in older hypertension patients with respect to dipper profile of their hypertension variation. Methods Ninty-six older hypertension patients were evaluated with respect to the relationship of AASI and office PP with TODs including microalbumin (MAU) levels of 24 hours, endogenous creatinine clearance rate, intima-media thickness(IMT),left ventricular mass(LVM), diastolic dysfunction. Results AASI was found to have independent positive correlation with (i)24-h urine albumin excretion(P<0.05) in older hypertension patients;(ii) IMT(P<0.01) in dipper form of hypertension variation. Conclusion The estimation of noninvasive indexs of arterial stiffness (AASI) offers valuable information on the basis of their association with TODs including MAU levels of 24 hours, IMT, left ventricular diastolic dysfunction in older hypertension patients regarding the dipper status of their hypertention variation.