段伟, 颜丙新, 刘伟, 孙喜红, 崔秀举, 鲁希茜, 姜文国. 济宁市狂犬病潜伏期影响因素研究[J]. 上海预防医学, 2018, 30(10): 848-851. DOI: 10.19428/j.cnki.sjpm.2018.18796
引用本文: 段伟, 颜丙新, 刘伟, 孙喜红, 崔秀举, 鲁希茜, 姜文国. 济宁市狂犬病潜伏期影响因素研究[J]. 上海预防医学, 2018, 30(10): 848-851. DOI: 10.19428/j.cnki.sjpm.2018.18796
DUAN Wei, YAN Bing-xin, LIU Wei, SUN Xi-hong, CUI Xiu-ju, LU Xi-xi, JIANG Wen-guo. Influence factors for rabies incubation period in Jining City[J]. Shanghai Journal of Preventive Medicine, 2018, 30(10): 848-851. DOI: 10.19428/j.cnki.sjpm.2018.18796
Citation: DUAN Wei, YAN Bing-xin, LIU Wei, SUN Xi-hong, CUI Xiu-ju, LU Xi-xi, JIANG Wen-guo. Influence factors for rabies incubation period in Jining City[J]. Shanghai Journal of Preventive Medicine, 2018, 30(10): 848-851. DOI: 10.19428/j.cnki.sjpm.2018.18796

济宁市狂犬病潜伏期影响因素研究

Influence factors for rabies incubation period in Jining City

  • 摘要:
    目的探讨狂犬病潜伏期的影响因素,为制定狂犬病防控策略,延长狂犬病潜伏期提供依据。
    方法对2006—2015年济宁市报告的87例狂犬病病例开展流行病学调查并进行分析。采用单因素分析(Mann-whitney U检验和Kruskal-Wallis秩和检验)及多因素分析(Cox比例风险回归模型)研究狂犬病潜伏期的影响因素。
    结果狂犬病潜伏期为3~7 345 d,平均潜伏期为65 d。单因素分析显示,暴露部位、暴露分级、暴露后免疫史、伤人动物种类4个因素对狂犬病潜伏期的影响有统计学意义(P < 0.05);多因素分析显示,暴露后免疫史、暴露分级、暴露部位是狂犬病潜伏期的影响因素,暴露后免疫接种者发病风险是未免疫者的17.48倍,头面部暴露者的发病风险是下肢暴露者的2.13倍。
    结论暴露后免疫史、暴露分级、暴露部位是狂犬病潜伏期的影响因素。

     

    Abstract:
    ObjectiveTo explore the influence factors of rabies incubation period, and provide scientific evidence for prevention and control of rabies and prolongation of incubation period.
    MethodsEpidemiological data on human rabies cases of Jining City occurring during 2006-2015 were collected. Univariate analysis and Cox proportional hazard regression analysis were used targeting at the influence factors for incubation period of rabies cases.
    ResultsThe study investigated a total of 87 cases, with average rabies incubation period being 65 days (ranging from 3 to 7 345 days). Single variable analysis showed that exposure grading, exposed sites, postexposure immune history and hurt animal species were related to the rabies incubation period with statistical significance(P < 0.05). Cox proportional hazard regression showed that postexposure immune history, exposure grading and exposed sites were the real factors influencing latent period. The onset risk of vaccinated presons was 17.48 times that of unvaccinated persons. The onset risk of exposure to head and face was 2.13 times that of lower limb exposure.
    ConclusionThe determinants affecting incubation period of rabies prove to be postexposure vaccination, exposure grading and exposed sites.

     

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