Abstract: Gut microbiota and its metabolites are closely related to the occurrence and development of coronary artery disease (CAD), and the association between TMAO(trimethy lamine-N-oxide) and CAD has been confirmed by multiple cohort studies.The prevention and treatment of CAD by regulating gut microbiota and its metabolites has become a research hot spot.This article mainly reviews the characteristics of gut microbiota and its metabolites and the research progress on the relationship between intestinal flora and coronary artery disease.