ObjectiveTo understand the status and knowedge， attitude， practice（KAP） of adolescent sexually transmitted disease（STD） patients in Shanghai， and provide evidence for the development of health interventions.

MethodsA cross-sectional study was conducted by anonymous interview survey using self-made questionnaires in patients during 2017.10.1-2017.12.31. Consecutive variables were analyzed using Mann-Whitney U test. Classification variables were analysed using Chi-square analysis and logistic analysis.

ResultsRegarding to sex and reproductive health， the knowledge awareness rate of STD patients was very low. The rate of correctly answering most questions was less than 5%. The patients were more open to risky sex， while the proportion of positive attitude towards safe sex was lower. Men were more open than women to risky sex. For example， 34.7% and 35.7% of men accepted homosexuality and one-night stand， respectively， but only 1.5% and 12.4% of women showed acceptance. There was statistically significant difference in knowledge scores of STD between different genders （P=0.020）. The knowledge score of female patients was higher than that of male patients. There were statistically significant differences in unsafe sex and preventive health care attitudes among patients of different gender （P<0.001） and sex orientation （P<0.001）. The attitudes of female patients were better than those of male patients， and the attitudes of heterosexual patients were better than those of sexual minorities. There was statistically significant difference in sexual behavior among patients with different sexual orientation （P=0.014）， and the behavior score of sexual minority patients was better than that of heterosexual patients. The influencing factors of sex and reproductive knowledge were gender （P=0.001） and native place （P=0.004）. STD knowledge level in females and Shanghai residents was higher than males and the non-residents.

ConclusionThere is a large gender difference in adolescent STD groups in Shanghai. Women， floating population and sexual minorities are vulnerable groups and need more social support. More health education should be targeted on the factors affecting reproductive health knowledge， and adolescent STD prevention strategies should be formulated.