ObjectiveTo analyze allergen-specific IgE （sIgE） in the serum of patients with allergic diseases， and provide the basis for clinical diagnosis and treatment.

MethodsThe serum sIgE of 29 902 patients with allergic diseases in Hangzhou City of Zhejiang Province was detected by ELISA， and the result was analyzed with gender， age， time distribution.

ResultsThe positive rate of total IgE （tIgE） in 29 902 patients with allergic diseases was 77.34%. The most common inhaled allergens were dust mite （36.75%）， ragweed （11.23%） and tree pollen （9.06%）， and the most common food allergens were egg protein （9.90%）， milk （8.88%） and crab （4.62%）. The positive rate of sIgE in men was higher than that in women. The positive rate of sIgE in people less than 18 years old was higher than that in people more than 18 years old. The positive rates of tree pollen sIgE decreased year by year. Most patients were allergic to one allergen， accounting for 52.52% of the total sIgE positive patients.

ConclusionDust mite， ragweed， tree pollens， egg protein and milk are important allergens in Hangzhou. The prevention and treatment of allergic diseases should focus on these allergens. We should understand that the distribution of allergens in different ages and genders is different， so the prevention and treatment should focus on different aspects.