Objective To study the epidemiological features of hand， foot， and mouth disease （HFMD） in Minhang District of Shanghai and to explore the possible effects of meteorological factors on the onset of HFMD， aiming to provide a reference for the prevention and control of HFMD.

Methods The incidence data of HFMD in Minhang District from 2014 to 2018 were collected for descriptive analysis. The data of meteorological factors that might affect HFMD were analyzed by Pearson analysis and multiple linear stepwise regression.

Results The average incidence rate of HFMD in Minhang District from 2014 to 2018 was 271.51 per 100 000. The incidence of Huacao， Pujiang and Maqiao community were the highest. The incidence of HFMD in males was higher than in females and the 0‒5 age group had the largest number of cases， mainly in scattered children and children in kindergartens. The results of multiple linear stepwise regression analysis showed that the incidence of HFMD was negatively correlated with the weekly average air pressure （b=-4.32， P=0.004）， and was positively correlated with the weekly minimum temperature （b=2.62， P=0.040） and the weekly average relative humidity （b=1.71， P=0.010）. The correlation with weekly average temperature， weekly maximum temperature， weekly precipitation， weekly average air pressure and weekly average water vapor pressure was not significant.

Conclusion Meteorological factors in Minhang District of Shanghai are closely related to the occurrence of HFMD. Comprehensive measures should be taken to prevent and control HFMD.