王霖, 杜映荣, 马志强, 李杰, 张淑琼, 汤晓青, 瞿春燕, 段亚茹, 李才信. 新型冠状病毒疫苗接种6个月后血清IgM和IgG抗体水平的分析[J]. 上海预防医学, 2022, 34(2): 126-129. DOI: 10.19428/j.cnki.sjpm.2022.21598
引用本文: 王霖, 杜映荣, 马志强, 李杰, 张淑琼, 汤晓青, 瞿春燕, 段亚茹, 李才信. 新型冠状病毒疫苗接种6个月后血清IgM和IgG抗体水平的分析[J]. 上海预防医学, 2022, 34(2): 126-129. DOI: 10.19428/j.cnki.sjpm.2022.21598
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WANG Lin, DU Yingrong, MA Zhiqiang, LI Jie, ZHANG Shuqiong, TANG Xiaoqing, QU Chunyan, DUAN Yaru, LI Caixin. Serum IgM and IgG antibody response six months post-COVID-19 vaccination[J]. Shanghai Journal of Preventive Medicine, 2022, 34(2): 126-129. DOI: 10.19428/j.cnki.sjpm.2022.21598
Citation: WANG Lin, DU Yingrong, MA Zhiqiang, LI Jie, ZHANG Shuqiong, TANG Xiaoqing, QU Chunyan, DUAN Yaru, LI Caixin. Serum IgM and IgG antibody response six months post-COVID-19 vaccination[J]. Shanghai Journal of Preventive Medicine, 2022, 34(2): 126-129. DOI: 10.19428/j.cnki.sjpm.2022.21598
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新型冠状病毒疫苗接种6个月后血清IgM和IgG抗体水平的分析

Serum IgM and IgG antibody response six months post-COVID-19 vaccination

    摘要
  • 摘要:
    目的 分析接种新型冠状病毒疫苗（简称“新冠疫苗”）后血清IgM和IgG抗体水平，为疫苗接种后抗体表达的研究提供参考信息。
    方法 收集2021年7—8月在云南省昆明市第三人民医院检测新冠IgM和IgG抗体的健康体检者980例为研究对象，分析其抗体水平情况。
    结果 接种疫苗后IgG抗体阳性469例，阳性率47.86%。其中，男性75例，阳性率39.06%，IgG水平0.618（0.180，2.526） AU·mL-1［M（Q1，Q3）］；女性394例，阳性率50.00%，IgG水平0.999（0.305，3.334） AU·mL-1。IgM抗体阳性53例，阳性率5.41%。其中，男性14例，阳性率7.29%，IgM 水平0.057（0.026，0.195） AU·mL-1；女性39例，阳性率4.95%，IgM水平0.047（0.027，0.110） AU·mL-1。年龄≤30岁组IgG抗体阳性男性和女性均最高，分别为25例和133例，阳性率分别为51.02%和55.88%。IgG抗体阳性率和IgG水平在性别中差异显著（χ2=7.401，D=0.135 1，P<0.05），IgM阳性率差异无统计学意义（χ2=1.656，P>0.05）。各年龄组中IgG抗体阳性以≤30岁组和51~70岁组较高，分别为158例和122例，阳性率分别为55.05%和52.36%，抗体水平分别为1.209（0.426，4.386） AU·mL-1和1.074（0.191，7.670） AU·mL-1。各年龄组IgG和IgM抗体阳性率和IgG抗体水平比较差异均有统计学意义（χ2=29.11、52.14，P<0.05），IgG和IgM抗体水平在各年龄组间经多组Kruskal⁃Wallis检验和Spearman相关性分析，显示两者间有较高的相关性，差异有统计学意义（r=0.836 4，H=64.82、20.09，P<0.05）。
    结论 接种新冠疫苗6个月后IgG抗体阳性率仍较高，IgM抗体阳性率较低。IgM和IgG阳性率和表达水平在青年和中老年人群中较高，在性别和年龄上其表达水平存在差异且具相关性。

     

    Abstract:
    Objective To determine the serum IgM and IgG antibody levels post-COVID-19 vaccination， and provide scientific evidence for COVID-19 antibody response after vaccination.
    Methods A total of 980 healthy persons were included in Kunming Third People’s Hospital from July through August， 2021， which had been vaccinated with COVID-19 vaccines and then tested for anti-SARS-CoV-2 IgM and IgG antibodies.
    Results After the COVID-19 vaccination， 469 persons （positive rate， 47.86%） were positive for anti-IgG antibody. Of them， 75 were males with （positive rate， 39.06%）， and the average IgG level was 0.618 （0.180， 2.526） AU·mL-1［M（Q1，Q3）］； 394 were females （50.00%）， and the IgG level was 0.999 （0.305， 3.334） AU·mL-1. In addition， 53 persons （5.41%） were anti-IgM antibody positive. Of them， 14 were males （positive rate， 7.29%）， and the average IgM level was 0.057 （0.026， 0.195） AU·mL-1； 39 were females （4.95%）， and the IgM level was 0.047 （0.027， 0.110） AU·mL-1. The positive rate of anti-IgG antibody was highest in those aged ≤30 years， which was 51.02% in male （n=25） and 55.88% in female （n=133）. The anti-IgG response differed significantly by gender （χ2=7.401， D=0.135 1， P<0.05）， whereas the anti-IgM response was not significantly different （χ2=1.656， P>0.05）. Among the age groups， anti-IgG antibody level was higher in those aged ≤30 and 51-70 years， with 158 （55.05%） and 122 （52.36%） persons， respectively； the average antibody level was 1.209 （0.426， 4.386） AU·mL-1 and 1.074 （0.191， 7.670） AU·mL-1， respectively. The differences in the positive rates of IgG and IgM antibodies and the levels of IgG antibodies among different age groups were statistically significant （P<0.05）. Using Kruskal-Wallis test and Spearman correlation analysis， it showed a high correlation between the IgG and IgM antibodies （r=0.836 4， H=64.82， 20.09， P<0.05）.
    Conclusion The Anti-SARS-CoV-2 IgG antibody remains high six months post-COVID-19 vaccination， while anti-IgM antibody is low. The IgM and IgG response are higher in the young and elderly. The response differs by gender and age， demonstrating a correlation.

     

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