上海市乳腺癌生存者膳食模式与心血管疾病风险关联性研究

Association between dietary patterns and cardiovascular disease risk among breast cancer survivors in Shanghai

  • 摘要:
    目的 探讨上海市乳腺癌生存者的膳食模式与心血管疾病之间的关联性,为进一步提高乳腺癌生存者的整体健康水平提供科学依据。
    方法 采用分层抽样方法,对上海市癌症康复俱乐部各区块站的乳腺癌生存者进行横断面研究,开展膳食调查,得到乳腺癌生存者的膳食数据。利用因子分析提取膳食模式,将每个膳食模式按得分等分为4组,Q1是低分位组,Q2Q3为中分位组,Q4是高分位组。采用logistic回归模型控制可能的混杂因素,并探索膳食模式与心血管疾病风险的关联性。
    结果 通过因子分析共提取出主食膳食模式、坚果奶类膳食模式、蔬菜水果膳食模式、高蛋白膳食模式这4种膳食模式。校正年龄、体重指数(BMI)、居住情况、身体锻炼活动等可能的混杂因素后发现,坚果奶类膳食模式Q2组的乳腺癌生存者心血管疾病风险(OR=0.734,95%CI:0.537~0.993)低于Q1组的乳腺癌生存者,Q4组的乳腺癌生存者心血管疾病风险(OR=0.670,95%CI:0.488~0.920)也低于Q1组的乳腺癌生存者。
    结论 坚果奶类膳食模式的高依从性与乳腺癌生存者的低心血管疾病风险相关,应采取个性化干预措施,促进乳腺癌生存者培养健康膳食习惯,预防心血管疾病的发生。

     

    Abstract:
    Objective To explore the association between dietary patterns and cardiovascular diseases (CVD) among breast cancer survivors in Shanghai, and to provide a scientific basis for improving their overall health.
    Methods A cross-sectional investigation was conducted utilizing stratified sampling to recruit breast cancer survivors from district stations affiliated with the Shanghai Cancer Rehabilitation Club. Dietary intake data were systematically collected through validated food frequency questionnaires. Factor analysis was employed to derive distinct dietary patterns from the dietary datasets. The scores for each dietary pattern were divided into four groups by quartiles. The scores of each dietary pattern were categorized into four groups based on percentiles, with Q1 representing the low-score group, Q2 and Q3 the medium-score groups, and Q4 the high-score group. Multivariate logistic regression models were implemented to adjust for potential confounders and explore associations between identified dietary patterns and CVD risk.
    Results Four dietary patterns were identified through factor analysis: staple-food, nut-dairy, vegetable-fruit and high-protein patterns. After adjusting for possible confounding factors, such as age, body mass index, living arrangement and physical activity, breast cancer survivors with a nut-dairy dietary pattern score in Q2 had a lower CVD risk (OR=0.734, 95%CI: 0.537‒0.993) compared to those in Q1. Similarly, survivors in Q4 of the nut-dairy pattern exhibited a reduced CVD risk (OR=0.670, 95%CI: 0.488‒0.920) compared to those in Q1.
    Conclusion Higher adherence to the nut-dairy dietary pattern is associated with lower CVD risk among breast cancer survivors. Personalized interventions should be implemented to promote healthy dietary habits and prevent CVD in this population.

     

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