Abstract: Objective: To understand the epidemiological characteristics of dog bite exposure among individuals treated at rabies post-exposure prophylaxis clinics in Suqian City from 2021 to 2024, providing a reference basis for optimizing the allocation of health resources and formulating scientific prevention and control measures. Methods: Data on individuals exposed to rabies and treated at Suqian's rabies exposure prevention and treatment clinics from 2021 to 2024 were collected. Descriptive epidemiological methods were used to analyze indicators including patient characteristics, exposure classification, animal species responsible for injuries, wound management, and vaccination status. Results: Between 2021 and 2024, the number of outpatient visits for rabies exposure prevention and management in Suqian City totaled 333 450. The median age of exposed individuals was 23 (9, 47) years. The highest proportion of exposed individuals was recorded in 2023 (27.09%); the majority were female (52.22%), aged 5-9 years (17.49%), other occupations (37.05%). The rabies exposure rate in Suqian City from 2021 to 2024 was 16.75‰. The overall rabies exposure rate showed an upward trend (χ²_trend = 1 994.80, P<0.001). The exposure rate among males was lower than that among females (χ² = 890.43, P<0.001). The highest exposure rate was observed in the 5-9 age group (χ² = 67 063.20, P < 0.001). The number of individuals seeking medical care for rabies exposure exhibited a weak bimodal distribution, with the primary peak occurring in August and the secondary peak in January. The primary animal responsible for injuries was the cat (53.70%), and the source of these animals was predominantly domestic pets (88.90%). The proportion of exposed individuals bitten by cats showed an upward trend from 2021 to 2024 (χ² _trend = 548.44, P<0.001). Grade III exposure accounted for the highest proportion (53.53%), and 301 652 cases (90.46%) presented within 24 hours of exposure. The rate of rabies vaccine administration among those with Grade II and III exposures was 99.95% (319 413/319 573); 64 042 individuals received rabies immunoglobulin or anti-rabies serum; 8 360 exposed individuals received tetanus vaccine, with the usage rate of tetanus vaccine among exposed individuals showing an upward trend (χ²_trend = 618.26, P<0.001). Conclusion: Between 2021 and 2024, the overall incidence of rabies exposure in Suqian City showed an upward trend, with a higher incidence among women than men. The incidence was particularly high among children and adolescents aged 14 and under, with the majority of injuries caused by cats; most injuries were inflicted by domestic animals. The overall uptake of tetanus vaccines showed an upward trend. Suqian City should step up health education on rabies exposure during January and August each year, with a particular focus on raising awareness of rabies exposure prevention among people under the age of 14 and those in high-risk occupations prone to dog bites; it should also strengthen the management of domestic animals and ensure that they receive regular rabies vaccinations, particularly pet cats. Medical staff at rabies prevention and treatment clinics should receive enhanced training on the management of rabies exposures and the completion of information system reports to ensure the standardized operation of these clinics.