上海市青浦区一起本地登革热聚集性疫情调查分析

Epidemiological investigation and analysis of a local dengue fever cluster outbreak in Qingpu District of Shanghai

  • 摘要:
    目的 分析2024年上海市青浦区一起本地登革热聚集性疫情的流行病学特征,为后续登革热防控提供参考依据。
    方法 以2024年上海市青浦区在国家传染病网络直报系统中报告的7例本地登革热确诊病例为研究对象,采用描述性流行病学方法,从发病就诊与报告、临床症状、发病前15 d的外出外来史及活动轨迹等维度开展调查分析。
    结果 该起疫情共报告7例病例,病例发病前15 d内均无登革热流行区旅行史,存在共同暴露环境及蚊虫叮咬史,呈本地聚集性传播特征。临床表现以发热(100.00%)和肌肉酸痛(42.86%)为主。7例病例登革病毒核酸检测结果均为登革病毒2型,基因测序发现属于Cosmopolitan基因型,病毒株与近年我国南方登革热流行株亲缘关系最近。
    结论 本次疫情可能是由登革热感染者短暂停留输入导致的本地人群继发感染疫情,输入来源地为我国南方登革热疫情流行地区。

     

    Abstract:
    Objective To analyze the epidemiological characteristics of a local dengue fever cluster outbreak in Qingpu District of Shanghai in 2024, and to provide a reference for subsequent dengue fever prevention and control.
    Methods Seven confirmed local dengue fever cases reported through the National Notifiable Infectious Diseases Surveillance System in Qingpu District of Shanghai in 2024 were selected as the research subjects. Descriptive epidemiological methods were used to conduct investigation and analysis from the aspects of onset, medical treatment and reporting, clinical symptoms, travel and contact history within 15 days before onset, and activity trajectories.
    Results A total of 7 cases were identified in this outbreak. None of the cases had a travel history to dengue-endemic areas within 15 days prior to onset, while all had shared exposure environments and mosquito bite histories, indicating a local clustered transmission pattern. The main clinical manifestations included fever (100.00%) and myalgia (42.86%). All 7 cases were positive for dengue virus serotype 2 (DENV-2) by nucleic acid testing. Genetic sequencing showed that the virus strains belonged to the Cosmopolitan genotype and were most closely related to the epidemic DENV strains circulating in southern China in recent years.
    Conclusion This outbreak might be a local secondary infection caused by the short-term stay of dengue fever-infected individuals, and the possible source of importation was dengue fever endemic areas in southern China.

     

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