老年人体重指数与高血压患病风险的meta分析

Meta-analysis of the relationship between body mass index and hypertension risk in the elderly

  • 摘要: 目的:系统评估老年人体重指数(BMI)与高血压患病风险的关系。方法:系统检索中国知网、维普中文科技期刊数据库、万方数据库、中国生物医学文献数据库、PubMed、Web of science、Cochrane Library、EMbase数据库,检索时限为2005年1月1日—2025年5月31日。由2位研究员独立进行文献筛选,数据提取与质量评价。应用RevMan5.3软件对已发布的有关老年人群BMI与高血压关系的研究结果进行meta定量综合分析,以比值比(OR)及其95%置信区间(95% CI)为效应指标,采用I2检验和Q检验进行异质性检验,并依据异质性大小选择固定效应或随机效应模型对老年人群BMI与高血压的关联进行定量合并。结果:共纳入28篇文献,包含281 548例研究对象。meta分析结果显示,与正常体重相比,低体重与老年高血压患病风险负相关(OR=0.58,95% CI:0.49~0.69);超重(OR=1.62,95% CI:1.50~1.75)和肥胖(OR=2.68,95% CI:2.38~3.00)则与老年高血压患病风险正相关。亚组分析显示,采用世界卫生组织(WHO)标准计算的超重和肥胖人群的OR值均高于中国标准,且肥胖亚组的风险增幅更为明显。结论:高BMI为老年高血压患病的重要关联因素,采用不同BMI标准会导致风险估计存在明显差异。对于中国老年人群的高血压风险筛查,采用中国BMI标准更具公共卫生实践意义。

     

    Abstract: Objective To systematically evaluate the relationship between body mass index (BMI) and hypertension risk in the elderly. Methods Systematic searches were conducted in databases, including China National Knowledge Infrastructure(CNKI), VIP Database, Wan Fang Database, PubMed, Web of Science, China Biology Medicine disc(CBM), Cochrane Library, and EMbase, with the search time frame spanning from January 2005 until May 2025. Two researchers independently performed literature screening, data extraction and quality assessment. RevMan 5.3 software was used to conduct a quantitative meta-analysis of published studies on the relationship between BMI and hypertension in the elderly, with the odds ratio (OR) and its 95% confidence interval (95% CI) as effect measures. Heterogeneity was assessed using the I2 statistic and the Q test. A fixed-effects or random-effects model was selected based on the degree of heterogeneity to quantitatively pool the association between BMI and hypertension in the elderly population. Results A total of 28 studies involving 281 548 subjects were included. Meta-analysis results indicated that compared with normal weight, underweight was negatively correlated with the risk of hypertension in the elderly (OR=0.58, 95%CI: 0.49-0.69), while overweight (OR=1.62, 95%CI: 1.50-1.75) and obesity (OR=2.68, 95%CI: 2.38-3.00) were positively correlated with an elevated risk. Moreover, subgroup analysis revealed that the odds ratios (OR) for overweight and obese individuals calculated referring to WHO standards were significantly higher than those based on Chinese standards, with the risk increase being more pronounced in the obese subgroup. Conclusion High BMI is a important factor associate with hypertension in the elderly. However, the application of different BMI criteria leads to significant differences in risk estimation. For hypertension screening among the Chinese elderly population, adopting the domestic Chinese BMI criteria may be of greater public health significance.

     

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